摘要
目的探讨过敏性紫癜(HSP)患者急性期的外周淋巴细胞免疫、体液免疫变化及其在HSP发病机制中的意义。方法采用流式细胞术(FCM)对35例HSP急性期患者外周血淋巴细胞及其亚群细胞进行定量检测;应用免疫比浊法对其外周血清免疫球蛋白及补体进行定量检测。结果HSP急性期患者CD4+,CD4+/CD8+,CD16+56+细胞均显著低于健康对照组(P<0.05,P<0.01,P<0.01),而CD19+细胞明显高于健康对照组(P<0.01),免疫球蛋白IgA含量高于健康对照组(P<0.01),均有统计学意义。结论HSP患者急性期存在细胞免疫功能及体液免疫失调,且与病情相关。提示可加用免疫调节剂治疗。
Objective To observe the changes of the functional states of lymphocyte subgroup and immunoglobulin level of patients with Henoch-Sehonlein（HSP） in aeute phase, and to explore their roles in the pathogenesis of HSP. Methods The immunoglobulin concentration was detected with nephelometer and lymphocyte subgroup CD3^＋ , CD4 ^＋ , CD8^＋ , CD4^＋ /CD8^＋ , CD19^＋ , CD16＋56^＋ level of acute state with tlow cytometry （FCM） . Results The contents of CD4^＋ in actue state, ratio of CD4 ^＋ /CD8^＋ , CD16 ＋ 56^＋ cell were lower than that in control group（ P 〈 0.05, P 〈 0. 01, P 〈 0.01 ） ; CD19^＋ cell were higher than that in control group （P 〈 0.01） . IgA concentration was significantly higher than that in control gruup. Conclusion There are abnormal changes in body fluid immunity and cell immunity in HSP aetue state,and related with progress of the ill.The immune regulation therapy can he used in routine.
出处
《潍坊医学院学报》
2006年第6期421-422,共2页
Acta Academiae Medicinae Weifang
