摘要
目的应用放大胃镜观察胃食管反流病内镜下表现,探讨其特征性微细结构表现。方法66例胃食管反流性疾病者(非糜烂性食管炎NERD44例、糜烂性食管炎EE12例、Barrett食管10例)和9名健康志愿者行24小时食管pH检测和放大胃镜检查,于病变部取活检行H.pylori检测。结果内镜下,NERD组77.2%患者齿状线呈锯齿状、三角形及舌形与正常对照组比较差异有显著性(P<0.01);EE组83.3%患者食管下段粘膜血管呈螺旋型、不规则型炎症性表现与NERD组比较差异有显著性(P<0.05);Barrett组100%患者齿状线下黏膜小凹形态呈分枝状、斑片状或绒毛状,与EE组相比差异有显著性(确切概率法P=0.0396)。结论放大内镜下胃食管返流病特征性表现对于胃食管反流病的诊断有重要意义。
Objective To observe the minimal changes of gastroesopha geal reflux disease（GERD）, and to explore its main magnified endoscopic characteristics. Methods sixty-six consecutive outpatients with GERD（44 nonerosive reflux diseases and 12 erosive esophagitis and 10 Barrett esophaguses） were enrolled in this study,9 healthy volunteers served as controis. All the subjects were assessed with 24-hour ambulatory esophageal pH monitoring and magnifying endoscope. Biopsy specimens were taken from the region of pathological changes for H. pylori infection examination. Results In magnifying endoscope, Z-line in 77.2 % of the NERD patients, were serrated - , triangular - , glossal - shaped, which significantly different from that of the contols（ P 〈 0.01 ）. In about 83.3% EE patients,the shape of mucosal blood vessels were helico - , irreg u- lar- shaped,which was significantly different from that in the NERD （P 〈 0.05）.The shape of mucosal pits were cladodromous, patching,and fluffiness in all the Barrett esophagus patients,which was significantly different from that of the EE（ P 〈 0.05） .Condusion Magnifing endoscopy is important for the precise diagnosis of GERD.
出处
《胃肠病学和肝病学杂志》
CAS
2006年第6期609-612,共4页
Chinese Journal of Gastroenterology and Hepatology
