摘要
目的通过测定子前期患者氧化应激产物和炎症标志物的水平,进一步研究子前期的发病机制。方法以53例子前期孕妇为研究组(其中轻度子前期32例、重度子前期21例),20例同期分娩的正常孕妇为对照组。检测血浆8-异前列腺素(8-isoprostane)、丙二醛(MDA)、氧化低密度脂蛋白(ox-LDL)和高敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的浓度。结果(1)子前期患者血浆8-异前列腺素、MDA、ox-LDL的浓度分别为(153.07±44.84)pg/ml、(5.25±0.11)μmol/L、(772.04±151.00)μg/L,均高于对照组[(82.86±20.91)pg/ml、(4.67±0.38)μmol/L、(431.45±200.69)μg/L,P<0.01、>0.05和<0.05];(2)子前期患者血浆hs-CRP、IL-6、TNF-α水平分别为(2.17±1.29)mg/L、(26.49±12.73)pg/ml、(18.47±4.17)pg/ml均明显高于对照组[(1.46±1.00)mg/L、(13.35±5.01)pg/ml、(8.86±1.39)pg/ml,P均<0.01];(3)子前期患者8-异前列腺素与hs-CRP、IL-6、TNF-α呈显著正相关(P<0.01),而MDA及ox-LDL均与hs-CRP、IL-6、TNF-α无相关性(P>0.05)。结论氧化应激及炎症反应可能在子前期中发挥重要作用,干预氧化应激及炎症反应可能有利于控制子前期的发生和发展。
Objective To investigate the changes of plasma markers of oxidative stress and inflammatory reaction in preeclampsia（PE） and to evaluate their clinical significance and interactions in the pathogenesis of PE. Methods A prospective study was conducted involving 53＂women with PE （study group： including 32 cases of mild PE and 21 severe PE） and 20 normotensive women（control group） in the third trimester. The plasma concentrations of high-sensitive C-reactive protein （hsCRP） ,interleukin-6 （IL-6）, tumor necrosis factor-alpha （TNF-α）, malondialdehyde（MDA）, ox-LDL and 8-isoprostane were determined. Results （1） The plasma concentrations of hs-CRP, IL-6, TNF-α, 8-isoprostane and ox-LDL were significantly higher in the study group [ （2. 17 ± 1.29）mg/L, （26. 49±12.73）pg/ml, （18. 47±4.17）pg/ml, （153.07±44.84）pg/ml, （772. 04±151.00）μg/L, respectively] than those of the control（P〈0.01 or P〈0.05）, while no significant difference were noted between the plasma levels of MDA between these two groups [（5.25 ± 0. 11）μmol/L vs （4.67 ± 0.38） μmol/L, P〉0.05]. （2）The plasma levels of hs-CRP,IL-6,TNF-α, and 8-isoprostane were markedly elevated in the severe PE group [（2. 84±1.76）mg/L, （27.27± 18.38）pg/ml, （22.13±12.35）pg/ml, （163. 994-51.01） pg/ml, respectively] than those in mild PE group（P〈0.01 or P〈 0.05）, while no significant difference was shown in the plasma levels of MDA and ox-LDL between the SPE and MPE group [（5.49±0.15） μmol/L vs （5.08±0. 19）μmol/L, P〉0.05; （809.29±211.83）μg/L vs （741.66±190.73） μg/L, P〉0.05]. （3） Plasma levels of 8-isoprostane were posi- tively correlated with that of hs-CRP, IL-6, and TNF-alpha in PE women （r=0. 618,P〈0.01; r= 0. 689,P〈0.01;r=0. 712,P〈0.01 respectively）, but no relationship was found between the levels of MDA, ox-LDL and that of hs-CRP, IL-6, and TNF-α （r=0. 168, P〉0.05; r=0. 113, P〉0.05; and r=0. 110, P〉0.05, respectively）. Conclusions Oxidative stress and inflammatory reaction play an important role in the pathogenesis of PE. Antioxidant and anti-inflammatory treatment may prevent the onset and progress of PE.
出处
《中华围产医学杂志》
CAS
2006年第6期392-395,共4页
Chinese Journal of Perinatal Medicine
