摘要
目的研究丹参对梗阻性黄疸患者围手术期肾功能的影响。方法80例患者随机分为两组,试验组40例除常规治疗外给予丹参注射液40mL静脉给药5d,对照组40例给予常规治疗。于术前1d,术后第2、6d分别抽取两组患者清晨空腹血样及采取24h尿样,检测血样尿素氮(BUN),肌酐(Cr)及24h尿肌酐水平,计算肌酐清除率(Ccr)。结果术后2d,Cr较术前升高,Ccr较术前降低,BUN与术前无差异。术后第6d,丹参组Cr、BUN、Ccr与术前无差异,而对照组Cr仍较术前增高,Ccr仍较术前降低。结论丹参对梗阻性黄疸患者围手术期肾功能有促进恢复作用。
Objective To investigate the effect of Salvia Miltiorrhiza （丹参） on renal function in perioperative patient with obstructive Jaundice Methods Eighty patients admitted for surgery treatment of obstructive jaundice were randomly divided into two groups, 40 patients each： the experimental group was administered with Salvia Mihiorrhiza injection for 5 days in the postoperative period; the contral group was treated with conventional therapy. The blood BUN and creatinine and 24 h urine creatinine collected on the last preoperative day and the second, sixth postoperative day were determined. The creatinine clearance rate （Ccr） was calculated. Results At the second postoperative day, the levels of Cr were significantly higher than those preoperatively and the Ccr were lower. At the sixth postoperative day, in experimental group, the levels of Cr and Ccr were not different from those preoperatively and in the contral group, the levels of Cr were still higher, Ccr were still lower. In the postoperative period, the levels of Cr in the experimental group were higher than the contral group and Ccr were lower. Conclusion In the perioperative period, Salvia Mihiorrhiza may show beneficial effect on renal function in patients with obstructive jaundice.
出处
《中国中西医结合外科杂志》
CAS
2006年第6期526-528,共3页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
关键词
丹参
梗阻性黄疸
肾功能
围手术期
Salvia Mihiorrhiza, obstructive Jaundice, renal function, perioperative period
