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肠道细菌易位与肝病高动力循环的研究进展 被引量:1

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摘要 研究表明:异常血管紧张继发的高动力循环在肝硬化发展中有着很重要的作用;另外,肝硬化患者常伴有内毒素水平的升高,且内毒素的升高程度与肝病的失代偿程度相平行。最初Vallance(1991)提出:来自肠源性细菌易位的内毒素引起舒血管物质生成增加,这可能是肝硬化患者发生体循环血管舒张和相关临床表现的重要因素,此后许多学者证明了这一观点。此外,高动力循环及门体分流加重了细菌易位,两者互为因果使原有病情恶化。本文就肠道细菌易位及以高动力循环为特征表现的门静脉高压症的发生及作用机制作一阐述。
出处 《临床肝胆病杂志》 CAS 2006年第6期468-470,共3页 Journal of Clinical Hepatology
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