摘要
目的检测妊高征患者血浆ET、CGRP及NO含量,探讨其与内皮细胞功能的关系及临床意义。方法ET、CGRP及NO3项指标均采用放射免疫分析。结果血浆ET、CGRP及NO水平正常妊娠组与正常非孕组比较差异无显著性(P>0.05);轻度妊高征组与正常妊娠组比较也无显著性差异(P>0.05);中及重度妊高征两组则3项指标与正常妊娠组比较均存在极显著性差异(P均<0.01)。结论妊高征患者血浆ET、CGRP和NO浓度的变化,为研究其发病机理提供了有价值的实验室依据。
Objective To investigate the clinical significance of changes of plasma ET, CGRP and NO levels in patients with pregnancy induced hypertension. Methods Plasma levels of ET, CGRP （ with RIA） and NO （with colorimetry ） were measured in 36 patients with pregnancy induced hypertension 30 women with normal pregnancy and 32 controls. Results Plasma levels of ET, CGRP and NO in normal pregnant women were not significantly different from those in controls （P 〉 0.05 ） and plasma levels of ET, CGRP and NO in patients with mild pregnancy induced hypertension （n = 12） were not significantly different from those in normal pregnant women （ P 〉 0.05 ）, However, plasma levels of ET in patients with moderate （ n = 14） and severe （ n = 10） pregnancy induced hypertension were significantly higher than those in normal pregant women, while levels of CGRP and NO were significantly lower （ all P 〈 0.01 ）. Conclusion Detection of changes of plasma ET, CGRP and NO contents in patients with pregnancy induced hypertension provides a valuable laboratory basis for study of relationship between endothelial cell function and pathogenesis of hypertension.
出处
《放射免疫学杂志》
CAS
2006年第6期487-488,共2页
Journal of Radioimmanology
