摘要
本文通过免疫组织化学技术对38例滋养细胞肿瘤组织 P53基因蛋白进行了检测,试图探讨 P53基因与滋养细胞肿瘤的关系。结果38例滋养细胞肿瘤中(葡萄胎10例、恶性葡萄胎10例、绒癌18例),恶葡阳性表达20%(2/10),绒癌阳性表达22.2%(4/18),有3例为高表达,10例良性葡萄胎均为阴性。结果提示:P53基因与滋养细胞肿瘤的生物学行为有密切关系。随着临床的进展,高表达增加。P53的检测可望成为预测滋养细胞肿瘤恶性发展的临床指标。
In order to detect the relationship between P53 gene and trophocyte Tumor,P53 gene pro- tein was studied in 38 cases of trophcyte tumor tissues by immunohistochemistry.The findings showed that the rate of positive expression was 20%(2/10)and 22.2%(4/18)in malignancy mole and chorioepithelioma malignum.respectively,among 38 cases of trophocyte tumor.with the high expression in 3 cases and the negative finding in 10 benign cases.The findings suggesting there was a high relationship between P53 gene and the biological behavior in trophoeyte tumor.
