摘要
观察了３１例溃疡性结肠炎患者的Ｔ细胞亚群、红细胞免疫粘附功能、血清ＳＯＤ活性、补体Ｃ３水平、免疫复合物（ＣＩＣ）含量、ＭＤＡ含量、外周血ＮＫ细胞活性等有关免疫生化指标。结果表明：大肠湿热组、脾虚挟湿组ＣＤ４、ＣＤ８均低于对照组。大肠湿热组红细胞ＲＣＩＡ、ＲＣＩＣ均低于正常对照组。大肠湿热组血清ＣＩＣ、ＭＤＡ、ＳＯＤ均高于正常对照组。提示红细胞免疫粘附功能下降，ＣＩＣ和ＬＰＯ上升可作为大肠湿热型客观指标。脾虚挟湿型辅助性Ｔ细胞下降明显，红细胞免疫粘附功能正常可作为该组客观指标参考。ＣＤ４／ＣＤ８降低可作为脾虚挟湿与大肠湿热相区别的诊断指标之一。
The paper observed erythrocyte immunity, T cell subgroup and contents of super-oxide dismutase (SOD) of 31 patients with ulcerative colitis with the purpose of the study on the internal connection between mechanism of ulcerative colitis immunity and differential classification in TCM (the intestine damp-heat and spleen difficiency). The result were: CD4 and CD8 in the groups of intestine damp-heat, spleen difficiency, compared with normal control group, were lower (CD4 P<0. 001. CD8 P<0. 05). In the group of intestine damp-heat erythrocytes RCIA, RCIC were lower than those in normal control group (P<0. 01, P<0. 05 ), Erythrocytes RCIA of spleen deficiency compared with those of the normal control group showed no difference (P>0. 05), blood serum CIC, LPO and SOD of intesting damp-heat group were much higher than those of the normal control group (P<0. 05, 0. 01, 0. 001). These suggest that the decrease of RCIA and the rise of CIC and lipidperoxide (LPO)may serve as the indicators for intestine damp-heat; in spleen difficiency group T cell was much lower than that in the normal control group, but spleen diffficiency erythrocytes RCIA were nomal. The lower CD4/CD8 may serve as differentiation from intestine damp-heat.
出处
《西安医科大学学报》
CSCD
1996年第3期356-358,共3页
Journal of Xi'an Medical University(Chinese)
基金
陕西省卫生厅中医管理局资助
关键词
溃疡性结肠炎
大肠湿热
脾虚挟湿
免疫生化指标
ulcerative colitis
intestine damp-heat
spleen difficiency
the objective indicators of immunity and biochemistry
