摘要
用低硒，低硒低蛋白质，低硒低蛋白质高锰半会成饲料喂大鼠。８周后处死。实验结果表明．低硒低蛋白质饲料使动物体重下降，心肌电镜所见，心肌细胞内水肿及少数线粒体空泡变，全血、心肌和肝脏ＧＳＨ－Ｐｘ活性下降、心肌ＣＣＯ初ＳＤＨ活性也有下降趋势。而低硒高锰和蛋白质缺乏的复合作用导致体重明显下降，电镜下显示心肌细胞内水肿，线粒体肿胀、弥漫空泡变，肌原纤维断裂、肌丝分解、全血、肝脏ＧＳＨ－ＰＸ活性和心肌ＣＣＯ、ＳＤＨ活性与低硒低蛋白质组比较明显下降。
According to the level of selenium(Se), Manganese(Mn) and protein in diet, Wistar rats were randomly divided into 3 groups: Group A (low Se and normal Mn,protein);group B(low Se,protein and normal Mn) ;group C(low Se,protein and high Mn). The animals were sacrificed after 8-week feeding. The results showed that edematous myocardial cells and degenerative vacuolaris of a few cardiac mitochondria were observed in group B,under electron microscope. The activity of GSH-Px in blood,heart and liver in group B was apparently lower than that of group A. The activity of CCO and SDH in cardiac mitochondria showed a decreasing tendency in group B. But edematous myocardia.cells, extensive degenerative vacuolaris of the cardiac mitochondria,interupt of myofibril and dissolution of myofilaments were observed in group C under electron microscope. The activity of GSH-Px in blood and liver and the activity of CCO and SDH in group C was apparently lower than that in group B.
出处
《中国地方病学杂志》
CAS
CSCD
1996年第6期330-333,共4页
Chinese Jouranl of Endemiology
基金
国家自然科学基金
