期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

IκBα突变体对树突状细胞成熟及其信号通路的影响 被引量：3

原文传递
导出
摘要 不成熟树突状细胞（DC）低表达共刺激分子，通过T细胞凋亡、无能及调节性T细胞增多等多种机制诱导免疫耐受。如何有效抑制DC成熟从而诱导免疫耐受是移植免疫的重要课题。不成熟DC发育为成熟DC主要由NF—κB信号通路控制。我们利用IκBα突变体（MMM）阻断NF-κB活化，观察它对DC成熟的影响。
作者 祝恒成 陈江华 何强 刘修恒 程洪涛
机构地区 武汉大学人民医院泌尿外科 浙江大学医学院附一医院肾病中心
出处 《中华实验外科杂志》 CAS CSCD 北大核心 2006年第12期1574-1574,共1页 Chinese Journal of Experimental Surgery
关键词 成熟树突状细胞 细胞成熟 信号通路 α突变体 IΚB NF-ΚB活化 免疫耐受 共刺激分子
分类号 R392 [医药卫生—免疫学]
  • 相关文献

参考文献5

二级参考文献17

  • 1张工梁 郑素琴 等.分离T、B淋巴细胞的简易方法[J].上海免疫学杂志,1986,6(3):184-184.
  • 2Brenan M, Puklavec M. The MRC OX-62 antigen: a useful marker in the purification of rat veiled cells with the biochemical properties of an integrin. J Exp Med, 1992,175 : 1 157.
  • 3Brenan M, Rees DJG. Sequence analysis of rat integrinaE1 and aE2 subunits: tissue expression reveals phenotypic similarities between intraepithelial lymphocytes and dendritic cells in lymph. Eur J Immuol, 1997,27,3 070.
  • 4Talmor M, Mirza A, Turley S, et al. Generation or large numbers of immature and mature dendritic cells from rat bone marrow cultures. Eur J Immunol, 1998,28=811.
  • 5Rauer O. Wohlleben G, Seubert S, et al. Analysis of maturation states of rat bone marrow derived dendritic cells using an improved culture technique. Histochem Cell Biol,2002. 117,351.
  • 6Brlssette Storkus C'S, Kettel JC. Whitham TF.et al. Fit-3 ligand (FL) drives differentiation of rat bone marrowderived dendritic cells expressing OX62 and/or CD161(NKR P1). J Leukoc Biol, 2002, 71:941.
  • 7Chen-Woan M, Delaney CP, Fournier V, et al. A new protocol for the propagation of dendritic cells from rat bone marrow using recombinant GM-CSF, and their quantification using the mAb OX-62. J Immunol Meth-ods,1995,178:157.
  • 8Jonuleit H, Schmitt E, Steinbrink K, et al. Dendritic cells as a tool to induce anergic and regulatooy T cells. Trends Immunology, 200I, 22: 394-400.
  • 9Morel PA, Feili-Hariri M, Coates PT, et al, Dendritic cells, T cell tolerance and therapy of adverse immune reactions. Clin Exp Immunol, 2003, 133 : 1-10.
  • 10Cruz MT, Duarte CB, Goncalo M, et al. Differential activation of nuclear factor kappa B subunits in a skin dendritic cell line inresponse to the strong sensitizer 2,4-dinitrofluorobenzene. Arch Derrnatol Res, 2002, 294: 419-425.

共引文献5

同被引文献31

  • 1俞静,林茂芳,牟海波,黄河,蔡真.抗CD47单抗对人树突状细胞的免疫调控作用及其机制探讨[J].中国病理生理杂志,2004,20(12):2248-2252. 被引量：3
  • 2Kusmartsev S, Gabrilovich DI. Role of immature myeloid cells in mechanisms of immune evasion in cancer. Cancer Immunol Immunother, 2006,55 : 237 -245.
  • 3Dunn GP,Oid LJ,'Schreiber RD,et al. The three ES of cancer immunoediting. Ann Rev Immunol,2004,22:329-360.
  • 4Boris S, David LK, David AB, et al. Proliferating brain cells are a target of neurotoxic CSF in systemic autoimmune disease. J Neuroimmunol, 2005,169 : 68-85.
  • 5Liu YJ. Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity. Cell, 2001,106(3) :259-262.
  • 6Sen R, Baltimoer D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell, 1986,46(5):705-716.
  • 7Hayden MS,Ghosh S. Signaling to NF-κB. Genes Dev, 2004,18 (12) :2195-2224.
  • 8Wu L, DAmico A,Winkel KD,etal. RelB is essential for the development of myeloid-related CD8alpha-dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells. Immunity, 1998,9 (6) :839-847.
  • 9Ouaaz F, Arron J, Zheng Y,etal. Dendritic cell development and survival require distinct NF-kappaB subunits. Immunity, 2002, 16(2) :257-270.
  • 10Guermonprez P,Valladeau J,Zitvogel L,etal. Antigen presentation and T cell stimulation by dendritic cells. Annu Rev Immunol,2002,20(4) :621-667.

引证文献3

二级引证文献7

中华实验外科杂志
2006年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部