摘要
目的探讨甲状腺功能亢进(甲亢)并发肝功能损害(HLI)的发病特点、临床相关因素及其防治策略。方法对1994年4月至2004年12月在我院诊治的260例甲亢住院患者进行回顾性调查,分析病程中发生HLI的情况。结果HLI发生率为44．23％(115／260例)。HLI程度与甲亢患者的年龄、病程、病情严重程度密切相关,而与性别无关。临床症状不典型。所有HLI患者在采取卧床休息、保肝、降酶及支持治疗的同时,分别给予抗甲状腺药物、放射性131碘和手术治疗控制原发病后,97例肝功能恢复正常,13例较前明显好转,4例仍在治疗观察中,1例失访,治疗有效率达95．65％,尚未发现复发及死亡病例。结论提高临床医师对HLI的认识,加强原发病的治疗,合理选用治疗方案,以有效地减少并预防HLI的发生。
Objective To appraise the clinical related factors, characteristics and strategy in prevention and therapeutics in hyperthyroidism liver injury（HLI）. Methods Clinical records of 260 hospitalized patients with hyperthyroidism from Apr 1, 1994 to Dec 31, 2004 were surveyed retrospectively. Analysis of liver injury was carried out during hospitalization. Results The incidence of hyperthyroidism liver injury was 44.23 % （115/260）. The severity of HLI was significantly correlated with age, course and degree of hyperthyroidism, but not with gender. Clinical symptoms of HLI were atypical. After treatments by bed rest, drug for protection of liver function, antithyroid drugs, radio-iodine（ I 131 ） therapy or surgery, the liver function returned to normal in 97/115 patients, improved in 13, still under treatment in 4, and one was lost in follow up. The effective rate was 95.65%, no recurrnce or death. Conclusions Rational treatment regime is important for hyperthyroid patients with simultaneous prevention of hepatic injury. （Shanghai Med J, 2006, 29：708-710）
出处
《上海医学》
CAS
CSCD
北大核心
2006年第10期708-710,共3页
Shanghai Medical Journal
