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R-or-S-Thalidomide合成新工艺的研究 被引量：2

New synthetic route of R-orS-Thalidomide
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摘要 沙利度胺（thalidomide）具有抗炎、免疫调节、治疗风湿性疾病和抗肿瘤等作用。近期对沙利度胺的研究热点集中于肿瘤治疗中抗血管生成，其作用机制是通过非白由基介导的DNA氧化损伤直接抑制肿瘤细胞的生长和存活，抑制肿瘤血管新生，抑制促瘤细胞生长因子的分泌，降低其活性；同时，它能有效抑制肿瘤坏死因子α（TNF-α），肿瘤坏死因子α具有调节宿主的防御功能及免疫调控功能；也有研究者认为沙利度胺可能通过抑制结合素β链阻止某些灵长目细胞中的细胞迁移。 A novel synthetic route of thalidomide was found. We synthesized the target compounds （R - or S - thalidomide） thnough six procedures starting from glutamic acid in an overall yield of 61%. The intermediates and targets compounds were identified by IR, ^1H NMR, and elemental analysis.
作者 向东 成丽 伍贤学 吴成龙 尹红梅 魏于全
机构地区 四川大学华西药学院 四川大学华西药学院现代药学专业教学中心室 玉溪师范学院化学系 四川大学华西医院生物治疗国家重点实验室肿瘤中心
出处 《化学研究与应用》 CAS CSCD 北大核心 2006年第11期1349-1352,共4页 Chemical Research and Application
关键词 沙利度胺 合成 勒弗肯斯试剂 抗肿瘤 thalidomide synthesis Nelfkens＇ reagent anti - tumor
分类号 O625.636 [理学—有机化学]
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参考文献10

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二级参考文献3

共引文献5

同被引文献12

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化学研究与应用
2006年 第11期

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