摘要
Thalidomide and its derivatives have great potentials in immune therapy. This research note presented that heating the mixture of phthalic anhydride or its chloro or nitro substituted derivatives and L-glutamine in vacuum afforded thalidomide 1 and its corresponding derivatives 2—5 directly in yields 24%47%. Among them, compound 4 is the material in the synthesis of 3-amino and 3-amino-3′-fluoro substituted thalidomide. Compared with traditional methods, this method is more direct and convenient.
Thalidomide and its derivatives have great potentials in immune therapy. This research note presented that heating the mixture of phthalic anhydride or its chloro or nitro substituted derivatives and Lglutamine in vacuum afforded thalidomide 1 and its corresponding derivatives 2-5 directly in yields 24 %-47%. Among them, compound 4 is the material in the synthesis of 3-amino and 3-amino-3′-fluoro substituted thalidomide. Compared with traditional methods, this method is more direct and convenient.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2005年第8期1477-1479,共3页
Chemical Journal of Chinese Universities
关键词
沙利度胺
衍生物
一步法
合成
Thalidomide
Derivatives
One-step method
Synthesis
