摘要
糖尿病周围神经病变（diabetic peripheral neuropathy，DPN）是糖尿病最常见的慢性并发症之一，发生最早。文献报道其发生率为25％～90％不等。DPN可累及感觉神经、运动神经和自主神经，但以感觉神经最为常见。不但引起糖尿病患者的病死率和致残率升高，而且带来了复杂的护理、医疗问题，也是造成糖尿病患者反复住院的主要原因。其发病机制尚未完全明了，但已知并非单一因素所致。近年来糖尿病并发症的临床及实验研究显示，代谢紊乱、血管损害、免疫因素均起作用，其中神经生长因子一直占有重要地位。
Diabetic peripheral neuropathy （DPN） is one of commonest chronic complications of diabetes, which occurs early. The references show that the incidence of DPN was between 25 % and 90 %. DPN involves in sensory nerve, motor nerve and autonomic nerve, mostly in sensory nerve. The increased mortality and mutilation rate,and accompanying with complicated nursing and medical problems are the main causes of repeated hospitalization. The pathogenesis of DPN is unclear. Now we know is not induced by simple factor. Recent clinical and experimental studys in complications of diabetes show that metabolic disorder, vascular lesion and immune factors,specieally nerve growth factor contribute to the genesis of DPN.
出处
《内蒙古医学杂志》
2006年第10期913-916,共4页
Inner Mongolia Medical Journal
关键词
神经生长因子
糖尿病周围神经病变
Nerve growth factor
Diabetic peripheral neuropathy（DPN）
