摘要
目的探讨小儿乙、丙型肝炎临床与病理的关系。方法①对我院小儿肝病科1983-2004年1694例小儿采用1秒钟肝穿法进行肝活检。②病毒性肝炎采用国内最新分型标准,对肝脏炎症活动程度分级(G0-4级),对纤维化分期(S0-4期)。结果①病毒性肝炎1505例,占88.8%,其中首位是乙型肝炎1230例(占81.7%),其次为丙型肝炎154例(占10.2%)。②小儿乙型肝炎中,261例(89.4%,261/292)慢性乙型肝炎患儿被误诊为“健康携带者”;小儿丙型肝炎中,19例(19/154,12.3%)慢性丙型肝炎患儿被误诊为“健康携带者”。结论目前我国小儿肝病病因中乙型肝炎占首位。当前在国内肝病诊治方案中,仅依据肝功能判断肝脏病变的存在和程度做为抗病毒治疗指征和判断预后,存在一定缺陷,须要进一步修正。
Objective To explore the relationship between clinical manifestations and pathological changes of children with hepatitis B and C. Methods ①The one-second liver biopsy was performed in 1 694 children with liver diseases treated in our hospital from 1983 to 2004. ② Diagnosis of viral hepatitis was based on the latest diagnostic criteria formulated by The Chinese Society of Infectious and Parasitic Diseases,in which the degree of hepatic inflammatory change activity was divided as 0-4 grade （G0-4）,and the hepatic fibrosis was classified into 4 periods （S0-4）. Results ①Of the 1 694 patients, 1 505 （88.8%） suffered from viral hepatitis, among whom 1 230 children suffered from hepatitis B （81.7%） and 154 from hepatitis C （10.2%）. ② The of 261 cases （89.4%, 261/292） of chronic hepatitis B and 19 cases （12.3%, 19/154） of chronic hepatitis C were misdiagnosed as ＂healthy carriers＂. Conclusions Hepatitis viruses are major etiological agents in children with liver diseases, among which HBV is ranked the first. It is not enough to judge existence and degree of liver impairment, supplement anti-viral treatment and determine the prognosis only by liver functional changes in the current diagnostic and therapeutic regimen formulated by the chinese society of infectious and parasitic diseases. Therefore, the regimen should be further modified.
出处
《传染病信息》
2006年第3期130-131,141,共3页
Infectious Disease Information
