摘要
糖代谢的衍生物甲基乙二醛等可通过糖化作用产生细胞毒性。乙二醛酶(GLO)Ⅰ是降解甲基乙二醛过程中起主要作用的酶,在多种肿瘤细胞内高表达,并导致肿瘤耐药。GLOⅠ抑制剂具有抗癌及逆转耐药作用,有望成为新的靶向抗肿瘤药,但其具体作用机制仍有待进一步阐明。
The glycation effect caused by glyoxal, methylglyoxal and other saccharide derivatives is toxic to cells. Glyoxalase （GLO） I plays an important role in the degradation of methylglyoxal. Overexpression of GLO I in many kinds of cancer cell lines is associated with muhidrug resistance. The GLO I inhibitors are potent antineoplastic agents and drug-resistance modulators and likely to become new targeting antineoplastic agents. But the detailed mechanism is still unrevealed.
出处
《国际肿瘤学杂志》
CAS
2006年第10期747-750,共4页
Journal of International Oncology
关键词
肿瘤
抗药性
抗肿瘤药
乙二醛
Neoplasm
Drug resistance
Antineoplastie agent
Glyoxal
