摘要
目的:观察高脂饮食条件下,糖尿病大鼠心肌细胞中脂质沉积及心肌细胞凋亡情况。方法:以高脂喂养糖尿病大鼠为研究对象,分别观察糖尿病组和对照组NO、NEFA、TG、TC、LDL、HDL、TC、心肌iNOS、心肌细胞凋亡百分率和脂质在心肌细胞中沉积情况。结果:糖尿病组血糖、NO、NEFA、TG、TC、心肌iNOS、心肌细胞凋亡百分率明显高于对照组,有统计学意义;病理学检查发现,糖尿病组大鼠心肌细胞中有大量脂质沉积。结论:高脂喂养可导致糖尿病大鼠心肌细胞中沉积大量脂质,同时出现心肌凋亡增加。
Objective： To investigate the lipidoses in heart cell and myocardium apoptosis of diabetic rat, feeded by high - lipid food. Methods： Diabetes and control group were investigated. The peripheral blood samples and heart were collected, plasma NO, NEFA, TG, TC, IDL- c and iNOS in heart, myocardium apoptosis rate were measured.To observe the lipidoses at heart- cell. Results： Plasma glucose, NO, NEFA, TG, TC and iNOS in heart, myocardium apoptosis rate with diabetes were higher titan controle; there are lot of lipid deposit in heart cell of diabetic rat. Conclusion： Lipid- toxicity could result in the increase of myocardium apoptosis rate and lipidoses in heart cell of diabetic rat.
出处
《华西医学》
CAS
2006年第4期765-766,共2页
West China Medical Journal
关键词
高脂喂养
糖尿病
心肌
凋亡
high-lipid feed
diabetes
myocardium
apoptosis
