摘要
目的：观察依那普利和螺内酯联合治疗老年心力衰竭的临床疗效和安全性。方法：68例老年心力衰竭患者随机分为治疗组和对照组。对照组使用洋地黄、利尿剂、硝酸酯类等药物常规治疗，治疗组在常规治疗的基础上加用依那普利10～20mg／d和螺内酯20～40mg／d。治疗前后测量血压、心率、血生化指标、评定心功能，治疗前后检查超声心动图。结果：治疗组血压下降、心率减慢、心功能明显改善（P〈0．01）。左室射血分数（LVEF）明显升高（P〈0．01）。左室舒张末期内径（LVEDD）、心肌耗氧指数和左室收缩末期内径（LVESD）明显降低（P〈0．01）。与对照组比较差异有显著性（P〈0．05）。结论：依那普利联合螺内酯治疗老年心力衰竭明显改善心功能，改善左室重塑、疗效显著。
Objective：To evaluate the efficacy of enalapril and spironolactone in the treatment of chronic heart failure（CHF）. Methods： We divided 68 patients with CHF randomly into treatment group（36cases） and control group（36cases）. The two groups were treated with the routine medicine,including digitalis, diuretics and niteates. Besides, Enalapril （10- 20mg/d） and spironolactone （20- 40mg/d） was added to the treatment group, and the treatment was lasted for 12 weeks. And the heart function was evaluated and heart rates and blood pressure were measured, and LVEF, LVEDD and LVESD were evaluated by echocardiography before and after the treatment. Results： After treatment, the heart function and LVEF significantly increased, while LVEDD, LVESD, blood pressure and heart rates decreased in the treatment group. There was significant difference between the two groups. Conclusion.Combination of enalapril and spironolactone is effective and safe in treating chronic congestive heart failure,which can obviously improve the remodeling of the left ventricle.
出处
《黑龙江医药科学》
2006年第5期18-19,共2页
Heilongjiang Medicine and Pharmacy
关键词
依那普利
螺内酯
心力衰竭
enalapril
spironolactone
congestive heart failure
