摘要
目的 了解乳腺恶性肿瘤在广东东莞市区的发病特点和规律.方法 对近5年经病理检查证实的523例乳腺恶性肿瘤进行统计学分析.结果 从2001年至2005年10月乳腺恶性肿瘤构成比由12.05上升至26.20,呈逐年上升趋势;发病高峰年龄组为40～50岁（28.3%）,其次为30～40岁组（23.9%）;好发部位均以左侧多见,多为单侧,偶尔可为双侧;肿瘤大小以2～5 cm多见（56.6%）;病理类型以浸润性导管癌（非特殊性）为多见（78.97%）;82.6%的患者有不同程度的淋巴结转移;免疫组化ER、PR、c-erbB-2、bcl-2、p53、nm23、CathD阳性表达率分别为59.06%、58.35%、64.14%、67.86%、63.67%、95.48%、61.90%.结论 本组结果与国内文献对比有较多相似之处,不同之处为良恶性之比和年轻女性乳腺癌构成比较高,患者手术时多为较晚期.
Objective To study the pathogenetic features of breast malignant tumors in Dongguan Region. Methods A statistic study was performed on 523 cases of breast malignant tumors which were confirmed by pathological examinations. Results The proportion of breast malignant tumors between 2001 and 2005, and the incidence rate of breast malignant tumors were elevated from 12.05 to 26.20. the most cases （28.30%） occurred in the age of 40 - 50 years old and the next occurred in the age of 30-40 years old（23.90%）. The most common sites were located in left, and occasionally in beth. Diameter of the tumor mostly was 2 - 5 cm （56.60%）. Among the malignant tumors, Invasive ductal carcinoma （not otherwise specified） was the common （78.97%）. 82.60% patients had the metastasis of lymph node. The positive rates of ER, PR, c-erbB-2, bcl-2, p53, nm23, CathD were 59.06%, 58.35%, 64.14%, 67.86%, 63.67%, 95.48% and 61.90% respectively. Conclusion The results of this statistical analysis axe similar to results of other domestic data, But the ratio between benign and malignant tumors and the proportion of breast malignant tumors in young women is higher, in which the patients axe usually operated in mare advanced stage.
出处
《诊断病理学杂志》
CSCD
2006年第5期368-370,I0015,共4页
Chinese Journal of Diagnostic Pathology
基金
东莞市科学技术局资助课题(B200517)。
关键词
乳腺肿瘤
统计学分析
病理学
免疫组化
Breast tumor
Statistical analysis
Pathology
Immunohistochemistry
