摘要
目的探讨乏氧心肌显像剂^(99)Tc^m-4,9-二氮-3,3,10,10-四甲基十二烷-2,11-二酮肟(HL91)用于诊断实验性缺血心肌的价值。方法建立大鼠心肌在体缺血再灌注模型,采用体外放射自显影法检测正常对照组(6只)、缺血再灌注组(8只)及无再灌注组(8只)鼠心肌对^(99)Tc^m-HL91的摄取。结果对照组和无再灌注组心肌未见局灶性放射性浓聚,再灌注组心肌非坏死区有较高放射性浓聚,与正常心肌组织的摄取比值为1.634±0.354。结论 ^(99)Tc^m-HL91表现出较强的亲乏氧组织特性,能较好区分存活和梗死心肌。
Objective ^99Tc^m-4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione dioxime （ HL91 ） was a newly developed hypoxic imaging agent. In the current experiment, we investigated the uptake and distribution of ^99Tc^m-HL91 in ischemic myocardium. Methods Rat models of myocardial ischemia were established. The myocardial uptake of ^99Tc^m-HL91 was observed and comparatively analyzed with autoradiography in control （n =6）, ischemia （n =8） and reperfusion （n =8） groups. Results No obvious accumulation of ^99Tc^m-HL91 was identified in the myocardium in both control and ischemic groups, but ^99Tc^m-HL91 was significantly taken-up by ischemic myocardium after reperfusion. The uptake ratio of ^99Tc^m-HL91 between ischemic and normal myocardium was 1. 634 ± 0. 354. Conclusion ^99Tc^m-HE91 is a potential marker of myocardial viability in early phase of reperfusion after acute myocardial ischemia.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2006年第5期280-281,共2页
Chinese Journal of Nuclear Medicine
