摘要
目的 探讨99Tcm 4 ,9 二氮 3,3,10 ,10 四甲基十二烷 2 ,11 二酮肟 (HL91)脑显像检测急性脑梗死乏氧脑组织的作用。方法 7例正常对照者和 2 1例急性脑梗死患者于起病 96h内进行脑99Tcm HL91SPECT显像和同机CT扫描 ,并进行图像融合 ,其中 3例首次显像阳性的患者于第 7～ 4 2天复查SPECT显像 (1例 3次 ,另 2例各 1次 )。结果 ①对照组未见脑实质有明显放射性浓集。② 2 1例患者中 ,14例为完全或部分前循环梗死 ,乏氧显像阳性 8例 ,阳性率为 38 1% ,乏氧区位于梗死灶周围。其中 3例起病后 7～ 4 2d病情好转者 ,复查SPECT乏氧显像仍呈阳性 ,但范围缩小。 7例腔隙性梗死者乏氧显像均阴性。结论 99Tcm HL91SPECT显像可显示脑梗死后脑乏氧组织。
Objective To investigate the detection of brain hypoxic tissue in patients with acute brain infarction using 99 Tc m-4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione dioxime (HL91) SPECT imaging. Methods Seven normal controls and 21 patients with acute cerebral infarction (internal carotid artery involved) underwent 99 Tc m-HL91 SPECT and CT simultaneously within 96 h after stroke onset,3 patients with positive images in first SPECT also did next SPECT 7 to 42 d post the onset. Results ① There was no obvious uptake in brain tissue in normal controls. ②In 21 patients with acute cerebral infarct,8 (38.1%) of 14 patients with total or partial anterior circulation infarct showed positive cerebral hypoxic images,generally distributing in the peripheries of the infarct. Three of the 8 patients still showed positive 99 Tc m-HL91 images 7 to 42 d after the onset of stroke,but the scopes were smaller than those observed in their first SPECT. The other 7 patients with lacunar infarct did not exhibit any increased 99 Tc m-HL91 activity. Conclusion 99 Tc m-HL91 SPECT imaging could detect brain hypoxic tissue after acute cerebral infarction.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2004年第4期236-237,i001,共3页
Chinese Journal of Nuclear Medicine
