摘要
【目的】观察埃索美拉唑和阿奇霉素联合治疗,幽门螺杆菌(Hp)感染的疗效。【方法】120例Hp阳性患者,随机分为治疗组(A组)和对照组(B组)。A组给予埃索美拉唑20mg,阿奇霉素0.25g,均2次/d,共7d;B组给予经典Hp根除治疗方案:奥美拉唑20mg,阿莫西林1.0g,替硝唑0.4g,均2次/d,共7d;7d后分别继续单独使用埃索美拉唑或奥美拉唑20mg,1次/d,连续7d。于用药前1d,用药后d1,d3,d7,按标准对上腹痛,反酸进行评分,其中上腹痛从严重程度和发作频率两个方面进行评估。记录患者有无出现不良反应。治疗结束后4周做14C-UBT检查,了解Hp根除情况。【结果】A组上腹痛消失率用药d1为56.1%,d3为89.4%;B组用药d1为21.4%,d3为60.7%,两组比较差异有显著性(P<0.05);A组反酸消失率用药d1为59.6%,d3为93.0%;对照组用药d1为19.6%,d3为64.3%,两组比较差异有显著性(P<0.05);服药d7,A组上腹痛、反酸消失率分别为98.2%、98.2%,B组亦分别为96.4%、94.6%,两组比较差异无显著性(P>0.05)。A组、B组HP根除率分别为91.2%(52/57)、91.1%(51/56)(P>0.05)。不良反应发生率两组分别为8.7%(5/57),10.7%(6/56),所有患者均未出现明显不良反应。【结论】埃索美拉唑和阿奇霉素二联疗法是一种高效、安全、经济的根除Hp方案。
[Objective]To study the efficiency of combined therapy of asomeprazole and azithromycin on eradication of Helicobacter Pylori. [Methods]One hundred twenty patients with established H. Pyloryi. infection were randomly divided into 2 groups： group A was the treating group while group B in control. Group A received asomeprazole 20mg bid plus azithromycin 0.25g bid for 7 days;Group B received the classical therapy on eradication of Helicobacter Pylori：omeprazole 20mg bid plus amoxicillin 1.0 bid and tinidazole 0.4 bid for 7 days;Group A and Group B were respectively given asomeprazole or omeprazole 20mg qd for the following continous 7 days. Acid regurgitation and upper abdominal pain were scored according to the criteria one day before using drugs and the first , the third, the seventh day after using drugs,while upper abdominal pain was evaluated and recorded in severity ,and frequency. Helicobacter Pylori status was determined by 14C urea breath test （^14 C-UBT）4 weeks after treating. [Results]The percentages of upper abdominal pain disappearance at the first day and the third day were 56.1% ,89.4%in group A and 21.4% ,60. 7%in gourp B,with statistical difference（ P 〈0.05） The treating group achieved better results than the control group（ P 〈0.05）. The percentages of acid regurgitation disapperance at the first day and the third day were 59.6% ,93.0% （group A） and 19.6 %, 64.3% （group B）, with statistical difference（ P 〈0.05 ） . The percentages of upper abdominal pain disapperance and acid regurgitation disapperance at the seventh day of the therapy were respectively 98.2%, 98.2% in group A, 96.4% ,94.6% in group B,with no statistical difference（ P 〉0.05）. Helicobacter Pylori was eradicated in 52 of 57 patients in group A（91.2%）and in 51 of 56 patients in group B（91. 1%） after the treatment,with no statistical difference （ P 〉0.05）. Percentage of side effects were 8.7% （5/57） in group A and 10.7% （6/56）in group B, All patients had no severe side effects. [Conclusion]The combined therapy of asomeprazole and azithromycin is highly effective in eradicating Helicobacter Pylori. This regimen is safe,reliable and economical.
出处
《医学临床研究》
CAS
2006年第10期1575-1577,共3页
Journal of Clinical Research
