摘要
目的：评价长疗程低剂量α－干扰素口含片治疗慢性乙型肝炎及丙型肝炎的疗效。方法：采用大样本随机双盲对照实验设计，以检验患者血清学指征为判断疗效的主要标志。结果：慢性乙型肝炎α－干扰素组血清ＨＢＶＤＮＡ阴转率、ＨＢｅＡｇ阴转率和抗－ＨＢｅ阳转率均显著高于对照组（Ｐ＜０．０５），而慢性丙型肝炎α－干扰素组血清ＨＣＶＲＮＡ阴转率亦显著高于对照组（Ｐ＜０．０５）。结论：长疗程低剂量α－干扰素口含给药治疗慢性肝炎与大剂量注射给药相比，其疗效相似，但其使用方便、价廉和副反应轻。
bjective:To eval uate the efficacy of long-term and low-dose human interferon-alpha in treatment of patients with chronic hepatitis B and C;Methods:A randomized double-blind controlled trial was conducted.A total of 185 cases(95 with chronic hepatitis B and 90 with hepatitis C)were di-vided into two groups given either by 200 U sublingual human interferon-alpha-nl tablet(Immulin)or placebo sucked daily for six months. Results:After the treatment 18 out of 49(36.73%)patients with chronic hepatitis B became HBV DNA negative,and anti-HBe seroconversion rate was 48.98% in the Immulin groupas compared with 17.39%(P<0.05)and 13.04%(P<0.01)in the placebo group,respectively.The HCV RNA negatie seroconversion rate was 37.84%in the Immulin group which was significantly higher than that of the placebo group( P<0.001).Conclusion:The data suggest that long-term ahd low-dose interferon-alpha sucked daily for six months is safe,effective and convenient for the treatment of HBV and HCV infections.
出处
《北京医科大学学报》
CSCD
1996年第6期442-444,共3页
Journal of Peking University(Health Sciences)
关键词
干扰素
乙型肝炎
丙型肝炎
药物疗法
Interferon-alpha/admin
Hepatitis B/drug ther
Hepatitis C/drug ther
