摘要
目的探讨胃癌组织中Survivin和NF-κB在胃癌中的表达及其相关性,并初步探讨Survivin和NF-κB相互作用机制。方法采用免疫组织化学技术S-P法检测60例胃癌组织及相应的癌旁组织及30例胃正常组织中Survivin和NF-κB的表达情况。结果Survivin和NF-κB在胃癌中的表达呈正相关(r=0.443,P<0.05),阳性表达率明显高于癌旁组织及胃正常组织(P<0.05);而癌旁组织阳性表达率高于胃正常组织(P<0.05)。结论survivin及NF-κB在胃癌组织中特异性高表达,在癌旁组织、胃正常组织中的弱表达或不表达,提示它们可能参与了胃癌的发生与发展。
Objective To investigate the expression of survivin, NF-κB and their clinical significance in gastric cancer. Methods Steptative-peroxidase-biotin immunohistochemistry technique was used to detect the expression of survivin and NF-κB in sixty gastric carcinoma specimens, sixty gatric mucosa membrane adjacent tumor specimens and thirty normal gastric mucosa membrane specimens. Results There was a positive correlation between the positive expression of survivin and NF-κB in sixty gastric carcinoma specimens（ r = 0.443, P〈 0.05）. The positive expression rate of survivin and NF-κB in gastric carcinoma was significantly higher than in mucosa membrane adjacent tumor and in normal gastric mucosa membrane（ P 〈 0.05, P 〈 0.05 ） ; The positive expression rate of survivin and NF-κB in mucosa membrane adjacent tumor was higher than in normal gastric mucosa membrane（P〈0.05） .Conclusion The expression of survivin and NF-κB in gastric carcinoma tissues is much higher than that in mucosa membrane adjacent tumor and in normal gastric muctric membrane which is weaker or no neuropilin-1 expression; It suggests that they may play an important role in gastric tumorigenesis and development.
出处
《广西医学》
CAS
2006年第10期1512-1515,共4页
Guangxi Medical Journal
