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Tim家族在免疫应答中的作用 被引量：3

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摘要 Tim(T-cell immunoglobulin and mucin-domain-containing molecule)家族是最近发现的基因家族,主要表达在免疫细胞表面,调节Th1和Th2细胞介导的免疫应答,在一些变态反应和自身免疫性疾病的发生和发展中发挥着重要的作用。当前研究主要集中在该家族中已发现的4个成员:Tim-1,表达在Th2细胞和活化的初始T细胞表面,为T细胞的活化提供协同信号,并促进细胞因子的分泌;Tim-2,仅在动物中发现,选择性地表达在Th2细胞表面,负调节Th2的增殖分化及细胞因子的产生;Tim-3,选择性地表达在Th1细胞表面,负调节Th1介导的免疫应答;Tim-4是Tim-1的天然配体,主要表达在活化的抗原提呈细胞(APC)表面。
作者 黄金波 胡丽华
机构地区 华中科技大学同济医学院附属协和医院
出处 《现代免疫学》 CAS CSCD 北大核心 2006年第5期434-437,共4页 Current Immunology
关键词 Tim家族 免疫应答 移植排斥
分类号 R392.1 [医药卫生—免疫学]
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参考文献19

  • 1Venkataraman C,Schaefer G,Schindler U,et al.Cutting edge:chandra,a novel fourtransmembrane domain protein differentially expressed in helper type Ⅰ lymphocytes[J].J Immunol,2000,165(22):632-636.
  • 2Bonecchi R,Bianchi G,Bordignon PP,et al.Differential expression of chemokine receptors and chemotactic responsiveness of type I T helper cells (Th1) and Th2[J].J Exp Med,1998,187(1):129-134.
  • 3Monney L,Sabato S,Catherine A,et al.Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease[J].Nature,2002,415(6871):536-541.
  • 4Sanchez-Fueyo A,Tian J,Picatella D,et al.Tim-3 inhibits T helper type 1-mediated auto-and allo-immune responses and promotes immunological tolerance[J].Nat Immunol,2003,4(11):1093-1101.
  • 5Sabatos CA,Sumone CK,Cha E,et al.Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance[J].Nat Immunol,2003,4(11):1102-1110.
  • 6Sanchez-Fueyo A,Zheng XX,Weber M,et al.Tracking the immunoregulatory mechanisms active during allograft tolerance[J].J Immunol,2002,168(55):2274-2281.
  • 7Ichimura T,Bonventre JV,Sanicola M,et al.Kidney injury molecule-1(KIM-1),a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain,is upregulated in renal cells after injury[J].J Biol Chem,1998,273(7):4135-4142.
  • 8Kaplan G,Totsuka A,Thompson P,et al.Identification of a surface glycoprotein on African green monkey kidney cells as a receptor for hepatitis A virus[J].EMBO J,1996,15(16):4282-4296.
  • 9Kuchroo VK,Freeman GJ.The Tim gene family:emerging roles in immunity and disease[J].Nat Rev Immunol,2003,3(6):454-462.
  • 10Umetsu SE,Wang-Ling L,McIntire JJ,et al.Tim-1 induces T cell activation and inhibits the development of peripheral tolerance[J].Nat Immunol,2005,6(5):447-454.

二级参考文献9

  • 1McIntire JJ, Umetsu SE, Akbari O, et al. Identification of Tapr(an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol, 2001, 2:1109-1116.
  • 2Chae SC, Park YR, Lee YC, et al. The association of Tim-3 gene polymorphism with atopic disease in Korean population. Hum Immunol, 2004, 65: 1427-1431.
  • 3Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum, 1988, 31: 315-324.
  • 4Monney L, Sabatos CA, Gaglia JL, et al. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature, 2002, 415: 536-541.
  • 5Sanchez-Fueyo A, Tian J, Picarella D, et al. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol, 2003, 4: 1093-1101.
  • 6McIntire JJ, Umetsu SE, Macaubas C, et al. Immunology:hepatitis A virus link to atopic disease. Nature, 2003, 425: 576.
  • 7Kuchroo VK, Umetsu DT, de Kruyff RH, et al. The TIM gene family: emerging roles in immunity and disease. Nat Rev Immunol, 2003, 3: 454-462.
  • 8Chae SC, Song JH, Pounsambath P, et al. Molecular variations in Th1-specific cell surface gene Tim-3. Exp Mol Med, 2004, 36:274-278.
  • 9陈红波,涂胜豪,胡永红.单核苷酸多态性在类风湿关节炎中的研究进展[J].中华风湿病学杂志,2004,8(3):171-173. 被引量：8

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现代免疫学
2006年 第5期

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