摘要
采用微量乙肝疫苗（总剂量为６μｇ）对ＨＢＶ高流行区居民进行随机对照研究，免疫Ⅰ组（疫苗＜８℃保存）Ｔ１２抗体阳转率和保护率分别为９０．８％和８７．０％，和对照组相比，差异显著（Ｐ均＜０．００１）；和常规剂量（总剂量９０μｇ）比，其抗体阳转率和保护率基本相同。提示ＨＢＶ高流行区可用微量乙肝苗代替常量乙肝苗进行预防接种。免疫Ⅰ组和免疫Ⅱ组（乙肝疫苗室温保藏２８℃±）免疫效果和保护率基本相同，认为室温条件下乙肝疫苗６个月内效价不变。
A randomized placebo controlled trial of very low dose hepatitis B vaccination (total 6μg,2μg each injection) was carried out in high risk population in Jiangsu,1991～1992.Three hundred persons,confirmed to be negative for HBV seromarkers,were equally divided into 3 groups :Vaccine Ⅰ group (vaccine kept below 8℃),Vaccine Ⅱ group (vaccine kept at room temperature) and control group (placebo). One year observation revealed the anti HBs positivity rate and efficacy rate respectively were 90.8% amd 87.0% in Vaccine Ⅰ group and 87.6% and 72.7% in Vaccine Ⅱ group,which were significantly higher than those in control group ( P <0.001) and are conparable to the results obtained by the use of conventional dosage of vaccine (total 90μg).The results also showed that storage of the vaccine at room temperature did not affect its safety, antigenicity and efficacy within 6 months.
出处
《徐州医学院学报》
CAS
1996年第3期257-260,共4页
Acta Academiae Medicinae Xuzhou
