摘要
采用微量乙肝疫苗（总剂量６μｇ）对ＨＢＶ高流行区的居民进行随机、对照研究，发现免疫Ⅰ组（疫苗＜８℃保存）Ｔ＿（１２）抗体阳转率和保护率分别为９０．８％和８７．０％，和对照组相比，有显著性差异（Ｐ＜０．０１）；和常规剂量（总剂量９０μｇ）相比，其抗体阳转和保护率基本相同。提示高流行区同样可以用微量乙肝疫苗进行预防。采用室温存放的乙肝疫苗作为免疫Ⅱ组进行免疫效果观察，其免疫效果和保护率与免疫Ⅰ组相比，基本相同。可以认为室温保存的乙肝疫苗６个月内可维持效价不变。本文还对其他问题进行了探讨。
randomised placebo-controlled trial of very-low-dose hepatitis B vaccine was carried in ahigh-risk pupulation in Jiangsu Salters. 300 healthy persons were confirmed to be negative for all HBV seri- omarkers. A 1-year observation showed that the anti-HBs positive rates in vaccine Ⅰ & Ⅱ groups were 90.8%& 87.6% respectively,and the efficacy rates 87.0%&72.7% respectively,which were obviously higher thanthose in the placebo-group. The results testify that the very-low-dose hepatitis B vaccine can be useful for theprevention of HBV infection in a high-risk population. Further sudy also found that the vaccination of hepati-tis B vaccine in the state of room-temperature 28℃ is similar to that in the state of lower temperature(8℃). Meanwhile,we researched other question in this study.
出处
《地方病通报》
1996年第2期39-41,共3页
Endemic Diseases Bulletin
关键词
乙型肝炎病毒
乙型肝炎疫苗
免疫
Hepatitis B virus
Hepatitis B vaccine
Efficacy evaluation
