摘要
为探讨表皮生长因子受体（ＥＧＦＲ）在良性前列腺增生（ＢＰＨ）中的作用，对３０例ＢＰＨ、１０例青年正常前列腺（ＹＮＰ）和８例老年非增生前列腺（ＯＮＰ）组织的ＥＧＦＲ、Ｔ及Ｅ２的含量进行分析。结果表明：ＢＰＨ组织中每ｍｇ蛋白ＥＧＦＲ含量（６４．８９±２５．０５ｆｍｏｌ／ｍｇ）显著高于ＯＮＰ组（２８．１３±５．７３ｆｍｏｌ／ｍｇ）（Ｐ＜０．０１），且ＥＧＦＲ与Ｔ之间相互调节关系较ＯＮＰ、ＹＮＰ组显著加强。提示ＢＰＨ中ＥＧＦＲ生物活性的提高及其与性激素调节关系的改变与ＢＰＨ的发生具有密切联系。
Quantitation of the saturable binding sites for radioiodinated EGF, testosterone (T)and estradiol (E2)were determined using EGF binding assay and radioimmunoassay in the prostate tissues from 30 patients with benign prostatic hyperplasia (BPH), 10 yung men with normal prostate (YNP)and 8 old men with non-hyperplastic prostate (ON P). The results showed the content of EGFR in BPH tissue was significantly higher than that in the ONP tissue(P<0. 01) and the correlation between EGFR and T became more close. This meant that the enhancing of biological active EGFR and the changing of relationship between EGFR and steroid hormone may play imortant roles in the development of BPH.
出处
《临床泌尿外科杂志》
北大核心
1996年第4期199-201,206,共4页
Journal of Clinical Urology
关键词
表皮生长因子
受体
前列腺增生
性激素
EGFR
Epidermal growth factor receptor Benign prostatic hyperplasia Steroid hormone
