摘要
目的:探讨非亲缘供者外周血造血干细胞移植(UD-PBSCT)治疗重型再生障碍性贫血(SAA)的可行性。方法:采用HLA-A 1个位点亚型不相合非亲缘供者的外周血造血干细胞治疗1例病程6年的SAA患者。预处理方案为环磷酰胺、足叶乙甙和抗人胸腺球蛋白,以霉酚酸酯、环孢菌素A、CD25单克隆抗体加短疗程的甲氨喋呤预防移植物抗宿主病(GVHD)。结果:移植后22 d中性粒细胞达到0.998×109/L,33 d血小板计数≥20×109/L,50 d血小板升至52×109/L,61 d血红蛋白升至104 g/L,无GVHD发生,移植后无病存活时间已达8个月。结论:UD-PBSCT可以使SAA患者短期内获得造血重建,可以作为治疗的选择。
Objective：To investigate efficacy of unrelated donor allogeneic peripheral blood stem cell transplantation （ UD- PBSCT） in treatment of severe aplastic anemia （SAA）. Methods： A 21 -year-old Chinese woman had been suffering from SAA for 6 years. We did not find any HLA-matched related donor for the patient. The patient was treated with PBSCT from a HLA-A-1- allele-mismatched unrelated donor with cyclophosphamide, etoposide and antithymocyte globulin for conditioning. Mycophenolate mofetil, cyclosporin A, CD25 antibody and short-term methotraxate were administered as graft versus host disease（GVHD） prophylaxis. Results：The absolute neutrophil count of 0. 998 ×10^9/L was achieved at 224 day, the platelet count≥20×10^9/L at 33^rd day, the platelet counted to 52×10^9/L at 50^th day, the hemoglobin counted to 104g/L at 61^rt day. Disease-free survival without GVHD was 8 months. Condusion：UD-PBSCT may be considered as a choice when hematopoietic stem cell transplantation is needed for SAA patients.
出处
《军医进修学院学报》
CAS
北大核心
2006年第5期334-336,共3页
Academic Journal of Pla Postgraduate Medical School
关键词
外周血干细胞移植
非亲缘
贫血
再生障碍性
移植物抗宿主病
peripheral blood stem cell transplantation
unrelated donor
anemia, aplastic
graft versus host disease
