摘要
不同价态的铬具有不同的毒性。三价铬[Cr(Ⅲ)]是人体内不可缺少的一种微量元素,但过量摄入也可能引起健康损害。一般认为六价铬[Cr(Ⅲ)]的毒性比三价铬大1000倍。人体通过各种途径接触或摄入过量含铬化合物均可能引起肾脏损伤,引起肾功能及尿中酶和蛋白含量的改变,严重的可能导致肾脏坏死。本文对含铬化合物在人体内的吸收与代谢及其对肾脏的损害方面的研究进展进行了综述。
The toxicity of chromium in different valent are quite different. Cr （ Ⅲ ） is a necessary trace element of human body, but excessive intake of Cr （Ⅲ ） may bring about health lesion, Cr （Ⅵ ） is generally considered 1,000 times more toxic than Cr （ Ⅲ ） . Renal damge may happen when people contact or intake excessive chromium compounds, The renal function and the concentration of enzyme and protein may be changed. Kidney necrosis can happen in heavy cases, The metaboly of chromium compounds and its nephrotoxicity were reviewed in this paper.
出处
《卫生研究》
CAS
CSCD
北大核心
2006年第5期659-662,共4页
Journal of Hygiene Research
基金
国家科技攻关计划项目资助(No.2003BA614A-13)
关键词
铬化合物
肾脏毒性
chromium compounds, nephrotoxicity, biomarker
