摘要
制备了数种作为ＳＯＤ模拟物的Ｃｕ（Ⅱ）－氨基酸络合物，在ｐＨ＝７．８及（２０．０±０．５）℃条件下，用细胞色素Ｃ法测定了各络合物对超氧阴离子自由基Ｏ－２歧化反应的催化活性，得到了催化速率常数ｋｃａｔ，其值比非催化速率常数ｋ提高了４～５个数量级。讨论了配体分子结构对络合物ＳＯＤ样活性的影响，并对实验结果作了初步解释。
Some copper(Ⅱ)-amino acid complexes as analogues of SOD were prepared.The activities of these complexes catalyzing dismutation of superoxide anion radical O-2 were measured by cytochrome C method at(20.0±0.5)℃and pH=7.8.The apparent catalytic rate constants kcat were obtained, these kcat are 104￣105 times the value of the noncatalytic rate constants.The effect of structure of ligand and molecules on the SOD-like activities of these complexes were discussed.
出处
《北京师范大学学报（自然科学版）》
CSCD
1996年第2期251-256,共6页
Journal of Beijing Normal University(Natural Science)
基金
国家自然科学基金
关键词
SOD模拟物
氨基酸
SOD样活性
铜配合物
superoxide anion radical
copper(Ⅱ)-amino acid complex
analogue of SOD
SOD-like activity
