摘要
目的:探讨刺五加注射液对多发性脑梗塞致血管性痴呆大鼠学习记忆的影响。方法:雄性Wistar大鼠36只,随机分为正常对照组、模型组及刺五加注射液组(90mg·kg-1)。将血凝块经颈内动脉注射,制作大鼠血管痴呆模型,通过Morris水迷宫实验、跳台实验及皮层和海马组织病理,观察刺五加注射液对血管性痴呆大鼠学习记忆相关指标及病理学改变。结果:与模型组比较,刺五加注射液组大鼠第2、5和6天达到平台的潜伏期均明显缩短(P<0·05),第1、2、5和6天到达平台的游程均明显缩短(P<0·05或P<0·01);寻找平台的策略由边缘型、随机型转为趋向型、直线型增快(P<0·05或P<0·01);第1天、第2天跳台的错误次数亦明显减少(P<0·05)。刺五加注射液对多发性脑梗塞血管性痴呆大鼠皮层及海马的病理变化无明显减轻。结论:刺五加注射液对多发性脑梗塞致血管性痴呆大鼠学习记忆有改善作用。
Objective To explore the effect of Acanthopanax senticosus injection （ASI） on brain multi-infract dementia rats. Methods Thirty-six male Wistar rats were randomly divided into 3 groups： control group, model group and ASI group. The multi-infract dementia rat models were set up by injecting mini-sludged blood in carotis internal arteries, learning and memory function of rats were determined by Morris water maze and Step-down test, the section of rat cerebral cortex and hippocampus were stained with haematoxylin eosin （HE）. Results Compared with model group, latency in ASI group shortened significantly at 2nd, 5th and 6th day, the distance shortened at 1st, 2nd, 5th and 6th day. The seeking tactics of ASI trgated rats improved in the Morris water maze test. The error times of ASI treated rats decreasd at 1st and 2nd day in Step-down test; ASI did not reduce significantly pathological changes of vascular dementia rats. Conclusion ASI has effect of treatment on multi-infract dementia rats.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2006年第5期812-815,共4页
Journal of Jilin University：Medicine Edition
基金
吉林省科学技术厅科研基金资助课题(20030551-1)
关键词
刺五加注射液
痴呆
血管性
学习
记忆
大鼠
Wistar
Acanthopanax senticosus injection
dementia, vascular
learning
memory
rats, Wistar
