摘要
目的：探讨来氟米特（LEF）治疗难治性儿童特发性关节炎（JIA）全身型的疗效和安全性。方法：对19例确诊为JIA（全身型）患儿加用来氟米特口服，首剂10～20mg／d，联用2d，然后根据体重确定剂量，体重〈20kg予5mg／d，体重20-40kg予7．5～10mg／d。体重〉40kg予15～20mg／d。观察治疗后4、8、12和26周的疗效和不良反应。并在4周内停用MTX，激素逐渐减量或停用。结果：LEF治疗4周有效率9．13％；8周有效率24．6％；12周有效率33．3％；26周有效率47．2％。26周体温控制的有效率仅为12、5％，关节症状改善的有效率可达68．4％。不良反应为肝功能异常、皮疹及胃肠道反应。结论：对于难治性儿童特发性关节炎全身型。LEF是一种安全有效的药物，对关节症状控制较好，但退热效果不理想。
Objective： To evaluate the efficiency and safety of leflunomide（LEF） in the patients with refractory systemic-onset juvenile idiopathic arthritis （JIA）. Methods： Nineteen patients with systemic-onset JIA received leflunomide tablet 10～20mg/d for two days; then the dosages were decided according to different weights, for those smaller than 20 kg, 5 mg daily; 20 - 40 kg, 7.5 - 10 mg daily; more than 40 kg, 15～20 mg daffy. Efficiency and drug safety was assessed at the end of4th, 8th, 12th and 26th week. In four weeks concomitant methotrexate was ceased. And prednisolone reduced or ceased. Results： Average improvement rate of leflunomide at 4th, 8th, 12th, 26th week was respectively 9.13%, 24.6%, 33.3%, 47.2%. Average improvement of arthritis was 68.4% at 26th week. But improvement of fever was only 12.5%. Side effects included leucocytopenia, raised aminotranderase and gastrointestinal response. Conclusions： LEF was safe and effective for patients with refractory systemic-onset juvenile idiopathic arthritis especially for arthritis, but was not effective for fever.
出处
《儿科药学杂志》
CAS
2006年第5期1-2,20,共3页
Journal of Pediatric Pharmacy
关键词
儿童
特发性关节炎
来氟米特
疗效
安全性
Juvenile
Idiopathic arthritis
Leflunomide
Efficiency
Safety
