摘要
以３％牛磺胆酸钠经胆胰管逆行注射制成大鼠急性出血坏死性胰腺炎（ＡＨＮＰ），并用丹参进行实验性治疗，发现对照组６ｈ出现严重的胰腺出血坏死及微血管破坏，血清胰酶活性显著升高（Ｐ＜０．００１），１２ｈ后血清胰酶活性呈进行性降低，胰腺微血管及组织病变进行性加重；丹参组２４ｈ胰腺微血管损害及组织学病变改善显著（Ｐ＜０．０１）。结果提示：微循环障碍是加重ＡＨＮＰ后期胰腺病变的重要因素，丹参能改变胰腺的微循环对ＡＨＮＰ有一定治疗作用。
After 96 rats were inflicted with acute hemorrhagic necrotic pancreatitis (AHNP) with retrograde injection of 3% sodium taurocholate into the biliopancreatic duct, 48 were treated with Danshen (Radix Salviae Miltiorrhizae) and the other 48 without treatment served as the control. It was found that there were severe hemorrhage, necrosis and microvascular lesions and the activity of pancreatic enzymes in serum was significantly increased ( P <0.01) in the 6th hour and the actitivity of the enzymes was decreased but the microvascular and panrenchymal lesions of the pancreas were progressively aggravated in the 12th hour after AHNP in the control. However, the microvascular and parenchymal lesions of the pancreas were significantly alleviated in the 24th h after AHNP in the treated group. Our findings suggest that the microcircular disorder is one of the factors to aggravate the pathological changes in the late stage of AHNP and Danshen can exert definite therapeutic effects on AHNP through the improvement of pancreatic microcirculation.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1996年第4期334-337,共4页
Journal of Third Military Medical University
