摘要
目的观察吸氧是否可以改善糖尿病性视网膜病变黄斑水肿（DME）。方法对6例（12只眼）糖尿病性视网膜病变黄斑水肿患者给予持续经鼻吸氧，4IM分，在治疗前、治疗3个月后、停止氧疗后3个月，分别用OCT测量视网膜厚度和检查最佳矫正视力。结果3个月氧疗后，全部病例12只眼黄斑厚度均降低。黄斑中心凹厚度（FTH）平均下降37．5％（范围14％～100％），黄斑中心平均厚度（CEN）平均下降42．1％（范围13％～100％），黄斑容积平均下降56．3％（范围36％～100％），（P〈0．01）。7只眼视力提高2行，4只眼无变化，1只眼视力下降1行。终止给氧3个月后，6只眼黄斑厚度较补氧3个月后增加。结论吸氧可降低DME黄斑厚度，并可作为治疗DME的一种辅助措施。
Objective Purpose Investigated the effect of retinal hypoxia by inspired oxygen in Diabetic macular edema （DME）. Methods Six patients with chronic DME received 4L/min of inspired oxygen by nasal cannula for 3 months. Retinal thickness was measured by optical coherence tomography（OCT） and best corrected visual acuity was assessed at baseline, during 3 months of oxygen treatment, and for 3 months after stopping oxygen. Results 12 of 12 with DME showed a reduction in thickness of the center of the macula after 3 months of inspired oxygen. Foveal thickness （ FTH）, excess foveolar thickness（CEN） and excess macular volume above the normal range was reduced by an average of 37.5% （ range, 14% - 100% ）, 42. 1% （ range, 13% - 100% ）, 56.3% （ range36% - 100% ） respectively, （ P 〈 0. 01 ）. 7 eyes showed increased at least by 2 lines, 1 eye declined by 1 line, and 5 eyes showed no change. 3 months after stopping supplemental oxygen, 6 of 12 eyes showed increased thickening of the macula compared with therapy of oxygen. Conclusions Supplemental oxygen may decrease macular thickness due to DME.
出处
《临床眼科杂志》
2006年第5期429-431,共3页
Journal of Clinical Ophthalmology
