摘要
P35蛋白是由杆状病毒入侵宿主细胞后自身编码的具有抗细胞凋亡活性的蛋白。P35蛋白能在哺乳动物、昆虫和线虫中抑制细胞的凋亡,是一种广泛有效的凋亡抑制因子。研究表明,P35蛋白通过与凋亡途径中的保守成分caspases结合并相互作用从而抑制caspases的活性而起作用。人类也存在类似的P35基因,其编码的P35蛋白具有独特的功能。P35蛋白的抗凋亡作用已开始被科学家们逐渐应用于生物、医学等领域,成为一个应用前景广泛的重要蛋白。
After invading host cells , Baculovirus itself can encodes a protein which is called P35 to inhibit cell apoptosis. Baculovirus P35 protein is a type of factors that has extensive and effective antiapoptosis function which does effects in mammals, insects and nematodes. Researchs show that P35 protein combine caspases, a conservative member in apoptosis, and inhibit its activity to make the antiapoptosis function. The effect of P35 has been utilized by scientists in biological, medical and other fields, and being expected a bright prospection.
出处
《中国优生与遗传杂志》
2006年第9期122-124,77,共4页
Chinese Journal of Birth Health & Heredity
