摘要
目的探讨2型糖尿病与骨质疏松症的相关因素及发生机制。方法2型糖尿病患者43例和正常对照43例,采用单光子吸收法测定尺、桡骨骨密度(BMD),以酶联免疫法分别测定空腹血清骨钙素(BGP)及晨尿中脱氧吡啶啉(DPD)值。结果2型糖尿病组的BMD低于正常对照组,BGP和DPD高于正常对照组。两组比较差异有非常显著性(P<0.01)。结论2型糖尿病患者骨形成减少,骨吸收增加,骨质疏松症发生率高。及早对糖尿病性骨质疏松进行防治有重要意义。
Objective To discuss the factors associated with osteoporosis in patients with type 2 diabetes mellitus and pathogenesis. Methods 43 patients with type 2 diabetes mellitus including 23 males and 20 females and healthy control inelduing 21 males and 22 females were selected. Single photon absorption was ued to determine the bone mineral density（BMD）of the elbow bone and radial bone. ELISA was used to determine serum osteecalein（BGP）, urine deoxypyridinoline（DPD）. Results The BMD of type 2 diabetes mellltus patients are lower than normal control group, The BGP and DPD in the diabetes group were significantly higher than the normal controls （ P 〈 0.01 ）. Conclusion Bone formation in type 2 diabetes mellitus patients is decreased and bone absorp- tion is increased. The incidence of osteoporosis in type 2 diabetes mellitus patients is high. It is of great significance to prevent and cure the osteoporosis in patients with type 2 diabetes mellitus early.
出处
《中国热带医学》
CAS
2006年第9期1635-1636,共2页
China Tropical Medicine
关键词
2型糖尿病
骨密度
骨钙素
尿脱氧吡啶啉
Type 2 diabetes mellitus
Bone mineral density
Osteocalcin
Urine deoxypyridinoline
