摘要
目的评价18F-FDG双探头符合线路显像及其同机CT图像融合在鼻咽癌患者中临床应用价值。方法89例鼻咽癌(NPC)病人(初发38例、放疗或放化疗后病人51例)进行18F-FDGSPECT显像及同机CT图像融合检查。结果与同期CT/MRI显像结果和3~6个月的临床追踪结果比较。结果18F-FDGSPECT符合显像诊断鼻咽部恶性病灶的敏感性、特异性和准确率分别为94.4%、85.7%和91.0%。解剖显像的诊断效能分别为77.8%、77.1%和77.5%(P<0.05)。其中FDGSPECT符合显像鉴别鼻咽癌放疗后的复发或残存敏感性、特异性和准确率分别为87.5%、85.7%和86.3%,解剖显像则分别为62.5%、77.1%和72.6%(P<0.05);18F-FDG显像有效地进行NPC临床分期,在初发NPC患者中6例分期上调,占(6/37)16.7%,7例分期下调,占(7/37)25%。对治疗后的患者能有效地评价治疗效果;同机CT图像融合能提供较可靠的定位诊断。结论18F-FDGSPECT显像在NPC诊断及分期中有实用价值,值得临床广泛应用。
Objective To evaluate the value of ^18F - FDG SPECT/CT coincidence imaging in the patients with nasopharyngeal carcinoma（NPC）. Methods 89 patients with NPC （38 primary cases and 51 cases after radiation therapy and chemotherapy） were underwent ^18F- FDG SPECT imaging and registration with integrated CT. The results were compared with those of CT/MRI and clinical fonowingsup for a period of from three to 6months. Results （1）^18F- FDG SPECT imaging showed that the sensitivity, specificity and accuracy in diagnosis of nasopharynx malignancy were 94.4%, 85.7% and 91.0%, respectively, higher than that of anatomical imaging of 77.8% ,77.1% and 77.5% （ P 〈 0.05）. The recurrent and residual sensitivity, specificity and accuracy in diagnosis of NTC by FDG SPECT after radiation therapy were 87.5%, 85.7% and 86.3%, respectively. （2）^18F- FDG SPECT was useful for clinical phasing of NPC and assessing results of treatment. （3） The image fusion with integrated X - ray CT could provide reliable localization of FDG imaging. Conclusion ^18 F - FDG SPECT/CT imaging possesses practical value in the diagnosis and phasing of NPC, and worthy to be popularized for clinical use.
出处
《中国热带医学》
CAS
2006年第9期1563-1565,共3页
China Tropical Medicine
