摘要
探讨了鸡卵白蛋白（ＯＶＡ）致敏的ＢＡＬＢ／ｃ小鼠经过ＯＶＡ雾化吸入刺激后，其支气管肺泡灌洗液（ＢＡＬＦ）中ＥＯＳ数量的变化。结果发现，以ＯＶＡ１０μｇ腹腔注射３次，间隔２周，然后给予５％ＯＶＡ雾化吸入２０ｍｉｎ，每天１次，共６ｄ，ＢＡＬＦ中ＥＯＳ数可达（９．６７±０．８０）×１０８／Ｌ．认为这是一种较理想的气道过敏性炎症模型。
This study described the changes of the eosinophil(EOS)counts in the bronchoalveo-lar lavage fluid(BALF)obtained from ovalbumin(OVA)-sensitized BALB/C mice.It was foundthat there was a severe eosinophilia in BALF(9. 76±0.80)×108/Lafter the mice were sensitizedwith 3 intraperitoneal injections of OVA(10μg per animal),and were then challenged with anaerosol of 5%OVA for 20 min, once a day for 6 days.This method produces an ideal allergic in- flammatory airway model.
出处
《广西医科大学学报》
CAS
1996年第2期15-19,共5页
Journal of Guangxi Medical University
基金
广西区科委自然科学基金
关键词
哮喘
变态反应
动物模型
asthma
allergy
infialnmation
eosinophil
