摘要
脂肪栓塞综合征（ＦＥＳ）主要表现为呼吸功能不全、ＰａＯ２下降、低氧血症而出现一系列病理改变。本实验应用高压氧（ＨＢＯ）对用骨髓制作的ＦＥＳ动物模型进行治疗。结果显示，ＨＢＯ能使ＰａＯ２明显升高；同时，由于ＰａＯ２升高，肺内渗出、水肿、出血等病变明显好转，机体状态获得改善。作者认为，提高ＰａＯ２在ＦＥＳ治疗中是关键，而ＨＢＯ是提高ＰａＯ２有效的方法之一，这为临床上应用ＨＢＯ治疗ＦＥＳ提供了实验依据。
Fatembolismsyndrome(FES)ismainlymanifestedbyaseriesofpathologicalchangesresultedfromrespiratoryinsuficiency,decreaseofPaO2andhypoxemia.Thepurposeofthepresentstudywastodeterminetheefficacyofhyperbaricoxygenation(HBO)forthetreatmentofexperimentalFES.TheanimalmodelsofFESwereproducedbyinjectingbonemarrowintotheauricularveinsof12rabbits.19,43and67hoursaftertheinjection,6animalsweretreatedwithHBOand6animalswereusedascontrols.FESmodelswereconfirmedbySudanⅢstainofthepulmonary,andlivertissue.PaO2determinationsweredonebeforebonemarrowinjection,priortoHBOtreatmentandalsobeforesacrificeoftheanimalsbyprocuringbloodsamplesfromthefemoralarteriesortheabdominalaorta.TheresultsshowedthatHBOsignificantlyenhancedPaO2,whichplayedthechiefroleinthetreatmentofFESandthatHBOisoneofthemostefectivemethodstoincreasePaO2.ThestudyprovidedatheoreticalbasisforthetreatmentofFESbymeansofHBO.
出处
《中华骨科杂志》
CAS
CSCD
北大核心
1996年第8期508-509,共2页
Chinese Journal of Orthopaedics
