摘要
目的:评价激素治疗脂肪栓塞综合征的益处和副作用。方法和结果:检索Medline、EMBase、及CNKI数据库,共找到7个关于激素预防多发骨折后脂肪栓塞的临床试验,其中5个为随机对照试验(RCT),Meta分析结果发现激素能明显降低脂肪栓塞的发生率[RR=0.15,95%CI(0.06,0.41)]。1994年到2005年6月CNKI数据库一共发表282个激素治疗脂肪栓塞的案例分析,包括2132例患者。激素治疗明显降低死亡和后遗症发生率,增加治愈率,但治疗剂量参差不齐。结论:激素可以有效预防和治疗脂肪栓塞,100～300mg小剂量氢化可的松能有效治疗多发骨折后的脂肪栓塞。而临床医生倾向于使用大剂量。
Objective:To evaluate the benefit and harm of corticosteroids treatment in fat embolism.Methods and Results:We searched Medline,EMBase,and CNKI databases.Seven clinical trials about cortcosteroids in the prophylaxis of fat embolism were found,among which five were RCTs,and four were included to a mate-analysis.Corticosteroids could significantly depress the incidence of fat embolism after multiple fracture[RR=0.15(0.06,0.41)].Furthermore,there were 282 case-reports,a tolal of 2132 patients,published in CNKI...
出处
《华西医学》
CAS
2007年第4期752-754,共3页
West China Medical Journal
关键词
脂肪栓塞
激素
预防
治疗
fat embolism
corticosteroid
prophylaxis
treatment
