摘要
观察了４２例冠心病患者血浆中氧化修饰低密度脂蛋白（Ｏ－ＬＤＬ）水平，与对照组相比有显著差异（８３．０±４８．１μｍｏｌ／Ｌ比４７．４±２０．２μｍｏｌ／Ｌ，Ｐ＜０．０１）；同时发现Ｏ－ＬＤＬ与高密度脂蛋白亚类Ⅱ（ＨＤＬ２）呈负相关（ｒ＝－０．３３，Ｐ＜０．０５）；在评估对冠心病的阳性频率中，发现Ｏ－ＬＤＬ与总胆固醇（ＴＣ）、低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）、血浆共扼双烯（ＣＤ）比较有较高的阳性频率，特别是当计算Ｏ－ＬＤＬ／ＬＤＬ－Ｃ比率时，其阳性频率更高．提示，Ｏ－ＬＤＬ在冠心病发病机理中可能发挥重要作用，而且比其它致动脉硬化原更有意义．由于发现ＨＤＬ２具有抗Ｏ－ＬＤＬ作用，所以更加说明提高机体内ＨＤＬ水平是相当重要的．
The paper observed the level of the plasma oxidative modification of low density lipoprotein (O-LDL) in 42 subjects with coronary heart disease and compared it with that of 45healthy control group (83. 0±48. 1 μmol/L vs 47. 4±20;2 μmol/L,P<0. 01)showing a significant difference between them, The study also showed a negative correlation between O-LDL and high density lipoprotein subclass Ⅱ(r=-0.33,P <0.05). In evaluation of the frequency percentage to coronary heart disease,the study found the frequency percentage of O-LDL was higher than that of TC, LDL-C, CD,especially that of the O-LDL/LDL-C ratio, which was the highest.The results suggest,O-LDL plays a more importanct role in the pathogenesis of coronary heart disease than other atherogenic substances,Because of the antioxidative activity of high density lipoprotein subclass,it is more importanct to raise high density lipoprotein level of the body.
出处
《临床心血管病杂志》
CSCD
北大核心
1996年第5期318-321,共4页
Journal of Clinical Cardiology
关键词
氧化修饰
低密度脂蛋白
冠心病
高密度脂蛋白
Oxidative modification of low density lipoprotein
Coronary heart disease
Antioxidation
High density lipoprotein
