摘要
应用高效液相色谱法检测１０例稳定型心绞痛（ＳＡ组）、１２例不稳定型心绞痛（ＵＡ组）、１２例急性心肌梗塞（ＡＭＩ组）患者、４２例正常人（对照组）的尿纤维蛋白肽Ａ（ＦＰＡ）水平，结果分别为：２８．１±１３．３、３９．６±１１．８、８８．２±２８．９、２５．４±１０．３ｎｇ／ｍｇＣｒ．ＡＭＩ组明显高于其它各组（Ｐ＜０．０１）ＵＡ组高于ＳＡ组（Ｐ＜０．０５）、对照组（Ｐ＜０．０１）．ＳＡ组与对照组的尿ＦＰＡ无显著差异．表明冠心病患者体内存在高凝状态．提示，尿ＦＰＡ的定量对冠心病类型的鉴别有一定价值，认为通过动态观察尿ＦＰＡ变化有助于判断病情．
The concentrations of urinary FPA were determinated by high performance liquid chromatography (HPLC)in 42 healthy individuals,10 patients with stable angina(SA), 12 patients with unstable angina(UA), 12 patients with acute myocardial infarction (AMI). Valuesmeasured in those groups were 25.4±10.3,28. 1±13.3,39. 6±11. 8and 88. 2±28.9ng/mg Cr respectively. The concentrations of urinary FPA in patients with AMI were significantly higher than that of healthy individuals,patients with SA or UA( P <0. 01,0.05). Urinary FPA in patients with UA were higher than that of patients with SA. There was no difference between patients with SA and the control in concentration of urinary FPA(P>0. 05). It was showed there would be a hypercoagulation in patients with coronary heart disease. It was also concluded that the urinary FPA might be helpful for differential diagnosis of coronary heartdisease. The resutls suggest that dynamic observation of urinary FPA may be helpful for evaluating severity of the disease.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
1996年第5期309-311,共3页
Journal of Clinical Cardiology
基金
国家科委"八五科技攻关"资助
关键词
高效液相色谱
纤维蛋白肽A
冠心病
尿
High performance
liquid chromatography
Urine fibrinopepride A Coronary heart disease
