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BRCA1对辐射诱发乳腺癌的作用研究进展 被引量：2

Progress of BRCA1 in radiation induced breast carcinoma
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摘要 抑癌基因BRCA1的突变几乎存在于所有遗传性乳腺癌与卵巢肿瘤的家属,大约一半家属仅发生乳腺癌,而且其遗传能增加发生乳腺癌和卵巢癌的概率也已被确认,但这种特殊肿瘤的易感性机制还尚未明确。抑癌基因BRCA1产物至少可以通过参与DNA损伤和修复反应途径发挥其肿瘤抑制功能。细胞对DNA损伤反应缺陷会诱发肿瘤,电离辐射可引起DNA簇损伤和双链断裂,成为细胞修复过程的问题。ATM、BRCA1和BRCA2三个基因的编码产物是正常细胞对DNA双链断裂反应所必不可少的,它们突变时就会诱发乳腺癌。其中BRCA1发挥重要作用。 The mutation of tumor suppressor gene BRCA1 is found in almost all of the families with inherited breast and ovarian cancers and about half of the families with only breast cancer, and that its inheritance can enhance the chances of breast and ovarian cancers, has been confirmed, but the mechanisms underlying this specific tumor susceptibility remain to be clarified. The breast/ovarian cancer suppressor gene BRCA1 and its products exert their tumor suppressor function, at least in part, by participating in DNA repair and/or DNA damage-responsive pathways. Deficiencies in cellular responses to DNA damage can predispose to cancer. Ionizing radiation can cause cluster damage and double-strand breaks （DSBs） that pose problems for cellular repair processes. Three genes （ATM, BRCA1, and BRCA2） encode products that are essential for the normal cellular response to DSBs, but predispose to breast cancer when mutated, and BRCA1 plays the principal role.
作者 宋学术 刘伟
机构地区 山东省医学科学院放射医学研究所
出处 《中华肿瘤防治杂志》 CAS 2006年第16期1265-1269,共5页 Chinese Journal of Cancer Prevention and Treatment
关键词 乳腺肿瘤/代谢 乳腺肿瘤/病理学 基因 BRCA1 综述文献 breast neoplasms/metabolize breast neoplasms/pathology gene, BRCA1 review literature
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献24

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二级参考文献19

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共引文献13

同被引文献16

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引证文献2

二级引证文献7

中华肿瘤防治杂志
2006年 第16期

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