摘要
目的:分析BGA-A、MDM2和HSP70在星形细胞瘤中的表达与肿瘤分化和预后的关系。方法:应用免疫组化SP法对54例脑原发性星形细胞瘤中BGA-A、MDM2和HSP70的表达进行观察,对其中41例取得随访资料的肿瘤患者存活因素进行分析。结果:BGA-A、MDM2和HSP70的表达与肿瘤分化和预后相关。MDM2在星形细胞瘤、间变型星形细胞瘤和多形性胶质母细胞瘤中差异有统计学意义,F=23·12,P0·01=5·61。BGA-A表达阳性和阴性的中位生存时间分别为23·5和16·5个月。MDM2和HSP70表达阳性中位生存时间分别为15·5和16·2个月,表达阴性中位生存时间分别为25·6和26·6个月。结论:BGA-A、MDM2和HSP70异常表达与星形细胞瘤分化和预后相关,可以作为判断肿瘤分化和预后的参考指标。
OBJECTIVE： To study the relationship between expressions of BGA-A, MDM2, HSP70 and cell differentiation and prognosis in astrocytoma. METHODS： Expressions of BGA-A, MDM2 and HSP70 in 54 cases of brain primary astrocytoma were evaluated with the immunohistochemistry S-P method. Among them, 41 cases of tumor with follow-up data and surviving factors were analyzed. RESULTS： The expressions of BGA-A, MDM2 and HSP70 in tumor were correlated with degree of malignance and prognosis. The expression of MDM2 in astrocytomas, anaplastic astrocytomas, glihlastoma showed a significant difference among the three groups, F= 23. 12, P0.01 = 5.61. In positive expression of BGA-A, the middle existence time was 23.5 months; negative expression of BGA-A, the middle existence time was 16.5 months. In positive expressions of MDM2 and HSP70, the middle existence, time was 15.5 months and 16.2 months; in negative expression of MDM2 and HSP70, the middle existence time was 25.6 months and 26.6 months. CONCLUSIONS： The aberrant expressions of BGA-A, MDM2 and HSP70.are associated with the differentiation grade and prognosis of the astrocytomas and which can be used as indicaters for the determination of differentiation and prognosis of astrocytomas.
出处
《中华肿瘤防治杂志》
CAS
2006年第16期1240-1243,共4页
Chinese Journal of Cancer Prevention and Treatment
关键词
星形细胞瘤
血型抗原
癌基因
热休克蛋白70
预后
astrocytoma
blood group antigens
oncogenes
heat-shock proteins 70
prognosis
