摘要
目的:考察鸡新城疫病毒Ⅳ系(NewcastlediseasevirusⅣ,NDVⅣ)活疫苗作为辅助治疗手段用于人类鼻咽癌患者的安全性、免疫学效应和临床效果。方法:以NDVLaSota株制备活疫苗,以喷雾吸入途径接种于家兔,得到了安全、有效的结果之后,再以相同途径接种于放射治疗后的鼻咽癌患者,观察其安全性、免疫学效果和辅助治疗的临床效果。结果:该疫苗接种于实验动物和肿瘤患者的近期毒副发应都属轻微,未见严重肝肾功能损害;血清均可测出相应的抗体,其几何平均滴度随接种程序的推进而相应升高;鼻咽癌患者接种该疫苗之后,3年复发率低于对照组(4·00%vs26·00%),差异有统计学意义;5年复发率亦低于对照组(14·00%vs28·00%),但差异无统计学意义。结论:鸡新城疫病毒Ⅳ系活疫苗接种于实验动物(家兔)和人,都具有良好的安全性;都能产生明显的免疫学效应;用于放射治疗后的鼻咽癌患者,能明显减少其治疗后3年复发率;因而,适宜作为一种辅助治疗手段,在临床上推广应用。5年或更长期的效果,尚待研究。
OBJECTIVE： To observe the safety, immunological effect, and clinical effect of Newcastle disease virus IV vaccine （NDV Ⅳ vaccine） when it was used as a supplement to treat the patients with NPC. METHODS： NDV La Sota vaccine was first used to rabbits, by means of spraying, to observe it＇s safety, immunological effect. When good result was got, the vaccine was then used to NPC patients who had had a radiotherapy, by the same means as used in rabbits. RESULTS.. Side effects of the vaccine, if any, were all slight and gentle, no matter being used to experimental animals or to cancer patients. No severe injury of liver or renal functions was found. Responsive antibodies could be detected in serum samples from experimental animals as well as from NPC patients, and the more the times of the vaccina tion, the higher titers in the serum. The relapse rate in 3 years was obviously lower in patients who had been vaccinated, compared with the corresponding rates in control patients （4.00% vs 26.00%）, and the difference was of statistical significance. The relapse rate in 5 years was also lower in vaccinated patients than that in the controls （14.00% vs 28.00%）, but, this difference was not of statistical sig nificance. CONCLUSIONS： NDV Ⅳ vaccine has good safety, could initiate obvious immunological effects, when it is used in rabbits as well as in human being. The 3-year relapse rate in radio-treated NPC patients could be obviously lower down by means of NDV IV vaccination. It is suggested that NDV Ⅳ vaccine could be clinically used as a supplement to the radio-treated NPC patients. The effect of this procedure in 5 years or more still remains to study.
出处
《中华肿瘤防治杂志》
CAS
2006年第16期1219-1221,共3页
Chinese Journal of Cancer Prevention and Treatment
基金
广西卫生厅基金资助项目(桂卫科Z200040)
关键词
鼻咽肿瘤/免疫学
病毒疫苗/药理学
新城疫病毒/免疫学
nasopharyngeal neoplasms/immunology
viral vaccines/pharmacology
Newcastle disease virus/immunology
