摘要
目的探讨母体低剂量铅暴露致后代神经行为发育损伤。方法受试母鼠与雄鼠同笼见阴栓开始分组试验:孕早期100mg/kg组和孕早期1000mg/kg组,于受孕0天灌胃给醋酸铅10ml/kg,直至仔鼠断乳,共染铅42d;孕晚期100mg/kg组和孕晚期1000mg/kg,于受孕第14天起给醋酸铅10ml/kg至仔鼠断乳,共染铅28d;另设对照组,给蒸馏水。围产期及哺乳期经口染铅。各组幼鼠出生后第5天测平面翻正、悬崖回避和负趋反射;第10天测前肢握力、空中翻正反射;于21d时,称重,脱椎取脑,称脑重。结果4个剂量染铅组仔鼠早期神经反射行为、早期运动能力的成熟有显著影响,并且随着染铅剂量的增加,接触铅的时间越早影响越大。结论铅经母体胎盘和乳汁影响了仔鼠,并对幼鼠神经行为产生了影响。
Objective To discuss whether the filial generation rats could be injured in neural behaviour development from low dose of lead acetate which were exposed to the parent rat during its pregnancy. Methods： At the first day of the pregnancy, the rats were divided into five groups, the first and second group are early pregnancy rats with 100mg·kg^1·d^-1 and 1000 mg·kg^-1·d^-1 lead acetate by gavage at 10 ml·kg^-1, total exposure 42 days, the third and fourth group are late pregnancy rat with 100 mg·kg^-1. dt and 1000 mg·kg^-1·d^-1 lead acetate, total exposure 28 days and the control group with distilled water. The offspring rats of each groups were tested for surface righting,cliff avoidance and slop turning at 5th day after birth, for body righting reflex and forelimb handgrip at 10th day. Result The offspring rats of four doses group have observably effects in early nervous reflex and locomotives, increasing with the exposure dosage and time. Conclusion Lead acetate affects offspring＇s early nervous reflex and early locomotives through the placenta and milk.
出处
《实验动物与比较医学》
CAS
2006年第3期140-143,共4页
Laboratory Animal and Comparative Medicine
基金
江西省卫生厅重大招标项目和指导项目资助
关键词
低剂量铅暴露
神经行为
损伤
仔鼠
Lead exposure
Nervous reflex and locomotives
Injury
offspring
