摘要
目的观察和比较腹腔化疗联合静脉化疗与单纯静脉化疗,对进展期大肠癌术后腹腔局部复发、肝转移率及3年生存率的影响和毒副作用。方法将60例大肠癌根治术后的进展期结直肠癌患者,随机分成腹腔化疗联合静脉化疗组(治疗组)和静脉化疗组(对照组)。结果治疗组3年腹腔局部复发率、肝转移率及3年生存率分别为13.3%、10.0%、86.7%,而对照组为43.3%、33.3%、53.3%,差异均有统计学意义(P<0.01),两组毒副反应差异无统计学意义(P>0.05)。结论影响大肠癌术后生存率的主要原因是癌细胞的肝转移和腹腔局部复发,而腹腔化疗联合静脉化疗(HLFO方案)对肝转移和腹腔局部复发的预防是非常有效的方法。
Objective To observe and compare the difference of the abdominal cavity recurrence rate, hepatic metastasis rate and 3 - yeat - survival rate of advanced colon cancer cases between abdominal cavity chemotherapy （ACC） combined vein chemotherapy （VC） and vein chemotherapy （VC）. Methods The total 60 advanced colon cancer cases who had radical operation were enrolled in this investigation randomly, 30 cases received ACC ＋ VC regimen （treating group） and 30 cases received VC regimen only（control group）. Results In treating group 3 - year- abdominal - recurrence rate, hepatic metastasis rate and 3 - year- survival rate were 13.3 %, 10.0%, 86.7 % respectively and in control group were 43.3 %, 33.0 %, 53.3 %. The difference has statistical significance（ P 〈 0.01）. There were no statistical significance in side effects of the two groups（ P 〉 0.05）. Conclusion Hepatic metastasis and abdominal cavity recurrence were the main reason to affect the survival rate of the colon cancer cases who have received radical operation. ACC combined VC regimen was an effective means to prevent it.
出处
《浙江临床医学》
2006年第9期916-917,共2页
Zhejiang Clinical Medical Journal
关键词
进展期大肠癌
腹腔化疗
静脉化疗
Advanced colon cancer Abdominal cavity chemotherapy Vein chemotherapy
