摘要
目的:探讨妊娠期急性脂肪肝(AFLP)的临床特点,以便早期诊断和及时治疗。方法:对近10年我院收治的9例AFLP患者的临床资料进行回顾性分析。结果:所有患者白细胞及尿酸均升高,8例纤维蛋白原降低,8例转氨酶升高,7例胆红素升高,7例空腹血糖降低,6例尿素氮升高,5例血肌酐升高,5例白蛋白降低,5例血小板降低、凝血时间延长。孕产妇治愈8例,死亡1例,死亡率为11%,11例围生儿中,存活7例,死亡4例,死亡率为36%。结论:对高危人群行产前筛查,可降低AFLP发病率;早期诊断、尽快终止妊娠和支持治疗是提高AFLP母儿预后的关键。
Objective：To explore the clinical features of acute fatty liver of pregnancy（AFLP） for early diagnose and management timely. Methods：The clinical findings and outcome of pregnancy were analyzed in 9 patients with AFLP at our hospital in recent 10 years. Results.WBC and uric acid elevated in all patients. Fibrinogen decreased and trensaminase elevated in 8 patients, bilirubin elevated in 7 patients, blood-fasting sugar decreased in 7 patients, urea nitrogen elevated in 6 patients,serum creatinine elevated in 5 patients,albumin decreased in 5 patients,platelet decreased and clotting time prolonged in 5 patients. 1 of 9 patients died, the mortality was 11%, 4 of 11 neonates died,bhe mortality was 36%. Conclusions：Pregnant women who are prone to suffer with AFLP,as well as their fetuses, should undergo antenatal screening testing. The key point to decrease the mortality of mother and children is to understand its characters,to make early diagnosis,and to termination of pregnancy timely.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2006年第9期546-548,共3页
Journal of Practical Obstetrics and Gynecology
关键词
妊娠期急性脂肪肝
诊断
治疗
Acute fatty liver of pregnancy
Diagnosis
Management
