摘要
为探讨经皮球囊二尖瓣成形术（ＰＢＭＶ）对二尖瓣狭窄（ＭＳ）血栓前状态（ＰＴＳ）的影响，检测２３例行ＰＢＭＶ病人术前和术后一周止血系统指标。根据术后二尖瓣口面积增加程度（ΔＭＶＡ）分为两个亚组：有效组（ΔＭＶＡ≤０．５ｃｍ２）８例、显效组（ΔＭＶＡ＞０．５ｃｍ２）１５例。发现术后血小板最大聚集率、血浆血栓素Ｂ２、全血粘度显著降低；抗凝血酶Ⅲ抗原和组织型纤溶酶原激活物显著升高；而血浆ＶｏｎＷｉｌｅｂｒａｎｄ因子抗原、纤溶酶原激活物抑制物、血浆粘度、红细胞比积无显著改变。在显效组，上述变化更为显著。提示ＰＢＭＶ可改善ＭＳ病人的ＰＴＳ。
Inordertoevaluatetheefectsofpercutaneousbaloonmitralvalvuloplasty(PBMV)ontheprethromboticstate(PTS)inpatientwithmitralstenosis(MS),thehemostaticparametersweredeterminedin23patientswithMSwhounderwentPBMVbeforeandoneweekaftertheproce-dure.Thepatientsweredividedintotwogroupsaccordingtothedegreeofincreaseinmitralvalvearea(ΔMVA):groupA(n=8)withsuboptimalresults(ΔMVA≤0.5cm2)andgroupB(n=15)withoptimalresults(ΔMVA>0.5cm2).AfterPBMV,plateletmaximalaggregation,plasmathrombox-aneB2concentrationandwhole-bloodviscositysignificantlydecreased,andtheconcentrationofplas-maantithrombinⅢantigenandtheactivityofplasmatissueplasminogenactivatorsignificantlyin-creased,whereasplasmavonWilebrandfactorantigen,theactivityofplasma,plasminogenactivatorinhibitor,plasmaviscosityandhematocritremainedunchanged.IngroupBtheforementionedchangesweremoresignificant.TheseresultssuggestthattheimprovementofPTSinpatientswithMScanbeachievedbyPBMVandiscloselyassociatedwiththedegreeofvalvedilatation.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
1996年第6期435-437,共3页
Chinese Journal of Cardiology
基金
湖北省自然科学基金
关键词
二尖瓣狭窄
气囊扩张术
mitralstenosisthrombosisbaloondilatation
